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低钾性甲状腺毒症性麻痹:欧洲人急性发作四肢轻瘫的罕见病因。

Hypokalemic thyrotoxic paralysis: a rare cause of tetraparesis with acute onset in Europeans.

作者信息

Bazzani M, Benati L, Bosi M, Iorini M, Panizza M

机构信息

Department of Internal Medicine, County Hospital of Asola, Italy.

出版信息

Ital J Neurol Sci. 1998 Oct;19(5):307-9. doi: 10.1007/BF00713857.

DOI:10.1007/BF00713857
PMID:10933451
Abstract

We describe a 21-year-old Italian male affected by hypokalemic tetraparesis with acute onset. In the emergency ward, the patient was agitated, with tachycardia (140/min) and systolic hypertension (180/70 mm Hg). He was not able to flex the lower extremities against a light resistance and furthermore, he was hypotonic and without tendon reflexes. One hour later he developed strength deficit of the upper extremities as well. Biochemical analyses revealed severe hypopotassemia (2.1 meg/l). After administration of 140 meq potassium phosphate, the patient began to improve, and 12 h after the onset he was able to walk normally. Successive investigations documented an undiagnosed case of Graves' disease. Thyrotoxic hypokalemic paralysis has been observed almost only in Asians, however, with this case and others reported, we believe that it should be considered as a cause of muscular paralysis also in Caucasians.

摘要

我们描述了一名21岁的意大利男性,突发低钾性四肢轻瘫。在急诊病房,患者烦躁不安,伴有心动过速(140次/分钟)和收缩期高血压(180/70 mmHg)。他无法抵抗轻微阻力屈曲下肢,此外,他肌张力减退且无腱反射。1小时后,他的上肢也出现了肌力减退。生化分析显示严重低钾血症(2.1 mmol/l)。给予140 meq磷酸钾后,患者开始好转,发病12小时后他能够正常行走。后续检查确诊为一例未诊断出的格雷夫斯病。甲状腺毒症性低钾性麻痹几乎仅在亚洲人中观察到,然而,通过该病例及其他报道,我们认为在白种人中也应将其视为肌肉麻痹的一个病因。

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引用本文的文献

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Hypokalaemia with paralysis: don't forget the thyroid.低钾血症伴瘫痪:勿忘甲状腺。
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本文引用的文献

1
PERIODIC PARALYSIS IN HYPERTHYROIDISM.甲状腺功能亢进症中的周期性麻痹
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2
The association of periodic paralysis and hyperthyroidism in Japan.日本周期性麻痹与甲状腺功能亢进症的关联。
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[Hypokalemic periodic paralysis: new advances].[低钾性周期性麻痹:新进展]
Schweiz Med Wochenschr. 1998 Feb 21;128(8):297-301.
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Thyrotoxic periodic paralysis in a black man.一名黑人男性的甲状腺毒症性周期性瘫痪。
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Thyrotoxic periodic paralysis terminated with intravenous propranolol.静脉注射普萘洛尔使甲状腺毒症性周期性麻痹得以终止。
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A calcium channel mutation causing hypokalemic periodic paralysis.一种导致低钾性周期性麻痹的钙通道突变。
Hum Mol Genet. 1994 Aug;3(8):1415-9. doi: 10.1093/hmg/3.8.1415.
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Hypokalemic thyrotoxic periodic paralysis in a Caucasian male with Graves' disease.一名患有格雷夫斯病的白人男性的低钾性甲状腺毒症性周期性麻痹。
J Endocrinol Invest. 1995 Mar;18(3):228-31. doi: 10.1007/BF03347807.
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[Periodic hypokalemic muscular paralysis. Clinical and metabolic study of a case of periodic paralysis in the course of Basedow's disease].
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Thyrotoxic periodic paralysis. Report of 10 cases and review of electromyographic findings.
Arch Intern Med. 1989 Nov;149(11):2597-600. doi: 10.1001/archinte.149.11.2597.