Wicks R C, Kohler P F, Singleton J W
Am J Dig Dis. 1975 Jun;20(6):518-22. doi: 10.1007/BF01074936.
To assess thymus-derived (T) lymphocyte function in hepatitis B infection, lymphocytes from patients with type B acute viral hepatitis and healthy carriers of the hepatitis B surface antigen, were compared to normal controlss using phytohemagglutinin (PHA) -induced blast cell transformation and sheep-cell rosette formation. Overall cell (T lymphocyte) -mediated immune function was similar with these in vitro assays in all three groups, except for decreases in total T cells in isolated patients with acute disease. Consequently, if a defect in cellular immunity exists in normal controls with persistent hepatitis B infection, it is probably specific for the antigens of the hepatitis B virus and not related to a generalized impairment of T-lymphocyte function.
为评估乙型肝炎感染中胸腺来源的（T）淋巴细胞功能，将B型急性病毒性肝炎患者和乙型肝炎表面抗原健康携带者的淋巴细胞，与正常对照者的淋巴细胞进行比较，采用植物血凝素（PHA）诱导的母细胞转化和绵羊细胞玫瑰花结形成试验。除了个别急性病患者的总T细胞减少外，在所有这三组中，这些体外试验所检测的总体细胞（T淋巴细胞）介导的免疫功能相似。因此，如果持续感染乙型肝炎的正常对照者存在细胞免疫缺陷，那么这种缺陷可能是针对乙型肝炎病毒抗原的，而与T淋巴细胞功能的普遍损害无关。
