急性和慢性肝炎中的淋巴细胞毒素。特性及其与循环T淋巴细胞变化的关系。
Lymphocytotoxins in acute and chronic hepatitis. Characterization and relationship to changes in circulating T lymphocytes.
作者信息
Dehoratius R J, Henderson C, Strickland R G
出版信息
Clin Exp Immunol. 1976 Oct;26(1):21-7.
Abstract
Serum lymphocytotoxicity (LCT) was detected in 49% of fifty-one patients with acute viral hepatitis and 72% of twenty-nine patients with chronic hepatitis. LCT was not detected in ten chronic carriers of hepatitis B surface antigen. Characterization of LCT revealed it to be active at physiologic temperatures and to be reactive against both T and B lymphocytes. The occurrence of LCT was transient in acute hepatitis and intermittent in chronic hepatitis. There was a significant inverse relationship between the percentage change in LCT over time and peripheral blood T-cell proportions amongst the patients studied. These findings indicate the importance of liver damage in the appearance of LCT and suggest that LCT may contribute to depressed lymphocyte function in liver disease.
摘要
在51例急性病毒性肝炎患者中，49%检测到血清淋巴细胞毒性（LCT）；在29例慢性肝炎患者中，72%检测到LCT。10例乙肝表面抗原慢性携带者未检测到LCT。LCT的特征显示其在生理温度下具有活性，并且对T淋巴细胞和B淋巴细胞均有反应。LCT在急性肝炎中呈一过性出现，在慢性肝炎中呈间歇性出现。在所研究的患者中，LCT随时间的百分比变化与外周血T细胞比例之间存在显著的负相关。这些发现表明肝损伤在LCT出现中的重要性，并提示LCT可能导致肝病中淋巴细胞功能低下。
相似文献
1
2
Serum lymphocytotoxins in inflammatory bowel disease. Studies of frequency and specificity for lymphocyte subpopulations.炎症性肠病中的血清淋巴细胞毒素。淋巴细胞亚群的频率及特异性研究。
Clin Exp Immunol. 1975 Sep;21(3):384-93.
3
T and B lymphocytes in the liver and peripheral blood of subjects with acute and chronic hepatitis.急慢性肝炎患者肝脏及外周血中的T淋巴细胞和B淋巴细胞
Z Immunitatsforsch Immunobiol. 1979 Mar;155(4):338-45.
4
Functional characterization of peripheral blood lymphocytes in chronic HBsAg carriers.慢性乙肝表面抗原携带者外周血淋巴细胞的功能特征
Clin Exp Immunol. 1986 Mar;63(3):498-507.
5
Cellular and humoral immune reactions in chronic active liver disease. I. Lymphocyte subsets in liver biopsies of patients with untreated idiopathic autoimmune hepatitis, chronic active hepatitis B and primary biliary cirrhosis.慢性活动性肝病中的细胞免疫和体液免疫反应。I. 未经治疗的特发性自身免疫性肝炎、慢性乙型活动性肝炎和原发性胆汁性肝硬化患者肝活检中的淋巴细胞亚群。
Clin Exp Immunol. 1982 Oct;50(1):17-24.
6
A prospective study of postacute viral hepatitis: the role of HBsAg.急性后病毒性肝炎的前瞻性研究：乙肝表面抗原的作用
Med Interne. 1986 Jan-Mar;24(1):19-22.
7
In-vitro cell-mediated cytotoxicity for autologous liver cells in chronic non-A, non-B hepatitis.慢性非甲非乙型肝炎中自体肝细胞的体外细胞介导细胞毒性
Clin Exp Immunol. 1986 Jan;63(1):147-55.
8
9
Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis.急性甲型、乙型及非甲非乙型肝炎中的肝脏自身反应性。
J Clin Lab Immunol. 1988 Jan;25(1):1-7.
10
T and B lymphocytes in patients with chronic active hepatitis (CAH).慢性活动性肝炎（CAH）患者的T淋巴细胞和B淋巴细胞
Clin Exp Immunol. 1977 Oct;30(1):4-9.
引用本文的文献
1
Mitogen responsiveness in viral hepatitis and chronic active hepatitis: the role of reversible suppressive influences.病毒性肝炎和慢性活动性肝炎中的有丝分裂原反应性：可逆性抑制影响的作用。
Gut. 1980 Sep;21(9):738-44. doi: 10.1136/gut.21.9.738.
2
Lymphocytotoxins in leprosy and in asymptomatic hepatitis B virus infection.麻风病和无症状乙肝病毒感染中的淋巴细胞毒素
Clin Exp Immunol. 1980 Feb;39(2):289-96.
3
Autoantibodies and serum inhibition factors (sif) in patients with myocarditis.心肌炎患者的自身抗体和血清抑制因子（SIF）
Klin Wochenschr. 1980 Mar 3;58(5):219-25. doi: 10.1007/BF01476967.
4
Anti-lymphocytotoxic antibodies in sera of Thai adults infected with Plasmodium falciparum or Plasmodium vivax.感染恶性疟原虫或间日疟原虫的泰国成年人血清中的抗淋巴细胞毒性抗体。
Clin Exp Immunol. 1980 Mar;39(3):663-7.
5
Cold-reactive lymphocytotoxins in Crohn's disease and ulcerative colitis. I. Incidence and characterization.克罗恩病和溃疡性结肠炎中的冷反应性淋巴细胞毒素。I. 发生率及特征
Clin Exp Immunol. 1982 Jul;49(1):67-74.
6
Cold-reactive immunoglobulin M antilymphocyte antibodies directed against B cells in Thai children with dengue hemorrhagic fever.针对泰国登革出血热儿童B细胞的冷反应性免疫球蛋白M抗淋巴细胞抗体。
J Clin Microbiol. 1983 Apr;17(4):672-6. doi: 10.1128/jcm.17.4.672-676.1983.
7
Characterization of cold reactive lymphocytotoxic antibodies in malaria.疟疾中冷反应性淋巴细胞毒性抗体的特征分析
Clin Exp Immunol. 1983 Feb;51(2):232-8.
8
Disordered immunoregulatory functions in patients with chronic active hepatitis.慢性活动性肝炎患者免疫调节功能紊乱
Clin Exp Immunol. 1982 Mar;47(3):595-605.
9
Lymphocytotoxic antibodies in primary biliary cirrhosis.原发性胆汁性肝硬化中的淋巴细胞毒性抗体。
Dig Dis Sci. 1985 Sep;30(9):829-33. doi: 10.1007/BF01309512.
10
Anti-lymphocytic antibodies in autoimmune chronic active hepatitis starting in childhood.儿童期起病的自身免疫性慢性活动性肝炎中的抗淋巴细胞抗体
Clin Exp Immunol. 1989 Jan;75(1):41-6.
本文引用的文献
1
MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS.人血清细胞毒素的微滴分析法
Nature. 1964 Dec 5;204:998-1000. doi: 10.1038/204998b0.
2
Rapid detection of Australia antigen by counterimmunoelectrophoresis.用对流免疫电泳法快速检测澳大利亚抗原。
J Immunol. 1970 Apr;104(4):1031-4.
3
Immunoglobulin spots on the surface of rabbit lymphocytes.兔淋巴细胞表面的免疫球蛋白斑点。
J Exp Med. 1970 Nov;132(5):1001-18. doi: 10.1084/jem.132.5.1001.
4
Separation of cells according to surface antigens by the use of antibody-coated columns. Fractionation of cells carrying immunoglobulins and blood group antigen.使用抗体包被的柱子根据表面抗原分离细胞。携带免疫球蛋白和血型抗原的细胞分级分离。
Scand J Immunol. 1972;1(1):75-87. doi: 10.1111/j.1365-3083.1972.tb03737.x.
5
T and B lymphocytes in acute and chronic hepatitis.急性和慢性肝炎中的T淋巴细胞和B淋巴细胞
Clin Immunol Immunopathol. 1974 Apr;2(3):353-60. doi: 10.1016/0090-1229(74)90053-1.
6
Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus.系统性红斑狼疮病程中的外周血淋巴细胞表面标志物
J Clin Invest. 1973 Dec;52(12):3046-56. doi: 10.1172/JCI107503.
7
Relative T-cell specificity of lymphocytotoxins from patients with systemic lupus erythematosus.系统性红斑狼疮患者淋巴细胞毒素的相对T细胞特异性
Arthritis Rheum. 1973 May-Jun;16(3):369-75. doi: 10.1002/art.1780160312.
8
Studies of T- and B-lymphocytes in patients with connective tissue diseases.结缔组织疾病患者的T淋巴细胞和B淋巴细胞研究。
J Clin Invest. 1973 Feb;52(2):283-95. doi: 10.1172/JCI107184.
9
Purification of human T and B lymphocytes.人T淋巴细胞和B淋巴细胞的纯化
J Immunol. 1974 Jan;112(1):420-3.
10
Antibodies to a specific surface antigen of T cells in human sera inhibiting mixed leukocyte culture reactions.人血清中针对T细胞特定表面抗原的抗体可抑制混合淋巴细胞培养反应。
J Exp Med. 1973 Oct 1;138(4):1021-6. doi: 10.1084/jem.138.4.1021.
Zotero 插件