Higgins G A, Shields T W, Keehn R J
Arch Surg. 1975 May;110(5):570-5. doi: 10.1001/archsurg.1975.01360110116019.
Over a five-year span 1,134 patients with asymptomatic solitary pulmonary nodules were entered into a cooperative study. Of the 392 lesions found to be primary bronchogenic carcinoma, 67 patients were living and under observation ten years following operation. In the study, 32% of lesions were primary bronchogenic carcinoma, the incidence being 51% in patients above the age of 50 years. "Curative" resection was possible in 309 patients (78.9%) with a five-year observed survival of 38.5% and a ten-year observed survival of 20.1%. Factors that influenced long-term survival were size of lesion, age at operation, and interval between the last normal and the first abnormal x-ray film. Histologic cell type and extent of resection were not found to influence long-term survival.
在五年时间里，1134例无症状孤立性肺结节患者参与了一项合作研究。在发现为原发性支气管肺癌的392个病灶中，67例患者术后十年仍存活并接受观察。在该研究中，32%的病灶为原发性支气管肺癌，50岁以上患者的发病率为51%。309例患者（78.9%）可行“根治性”切除，五年观察生存率为38.5%，十年观察生存率为20.1%。影响长期生存的因素有病灶大小、手术年龄以及最后一次正常胸部X光片与第一次异常胸部X光片之间的间隔时间。未发现组织学细胞类型和切除范围对长期生存有影响。
