Department of Surgery, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue Mailstop LKSD 5047, Cleveland, OH 44106, USA.
Surg Clin North Am. 2011 Feb;91(1):249-66. doi: 10.1016/j.suc.2010.10.012.
Functional imaging using radiolabeled probes that specifically bind and accumulate in target tissues has improved the sensitivity and specificity of conventional imaging. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) has shown improved diagnostic accuracy in differentiating benign from malignant lesions in the setting of solitary pulmonary nodules. FDG-PET has become useful in preoperative staging of patients with lung cancer, and is being tested with many other malignancies for its ability to change patient management. This article provides an overview of the current status of FDG-PET and presents the challenges of moving toward routine use.
放射性标记探针的功能成像，特异性结合并在靶组织中积累，提高了传统成像的灵敏度和特异性。氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）在鉴别孤立性肺结节中的良恶性病变方面显示出提高了诊断准确性。FDG-PET 已成为肺癌患者术前分期的有用手段，并正在与许多其他恶性肿瘤一起进行测试，以评估其改变患者管理的能力。本文概述了 FDG-PET 的现状，并提出了向常规使用迈进的挑战。
