Parmley R T, Spicer S S, Pratt-Thomas H R, Morgan S K, Othersen H B
Arch Pathol. 1975 May;99(5):259-66.
Ultrastructural examination of lymph nodes from patients with untreated Hodgkin disease showed unique spherical structures that were found extracellularly and within vacuoles of reticulum cells, macrophages, mononuclear cells, and occasional tumor cells. These spheroids varied in size and internal composition possibly in relation to developmental stages, and resembled mycoplasma morphologically and in cellular distribution. The spheroids were found predominantly in the neoplastic areas in lymph nodes of four out of nine patients with Hodgkin disease of the mixed cell variety, but were not seen in other types of Hodgkin disease or reticulum cell sarcoma. The structures were much more numerous in the lymph nodes from young children with Hodgkin disease. A lymph node of one child, disclosed numerous extracellular structures resembling viral type C particles in addition to mycoplasma-like spheroids. The results indicate that subclinical infections may occur in Hodgkin disease and contribute to the histopathologic manifestations of the disease.
对未经治疗的霍奇金病患者的淋巴结进行超微结构检查发现，有独特的球形结构存在于细胞外以及网状细胞、巨噬细胞、单核细胞和偶尔的肿瘤细胞的液泡内。这些球体大小和内部组成各异，可能与发育阶段有关，在形态和细胞分布上类似于支原体。在9例混合细胞型霍奇金病患者中，有4例患者的淋巴结肿瘤区域主要发现了这些球体，但在其他类型的霍奇金病或网状细胞肉瘤中未见到。在患有霍奇金病的幼儿淋巴结中，这些结构要多得多。一名儿童的淋巴结除了支原体样球体之外，还发现了许多类似C型病毒颗粒的细胞外结构。结果表明，霍奇金病可能发生亚临床感染，并导致该疾病的组织病理学表现。
