Parmley R T, Spicer S S, Wright N J
Lab Invest. 1975 Apr;32(4):469-75.
Numerous basophils were identified ultrastructurally in a tumorous lymph node from one of 10 patients with Hodgkin's disease. The tissue basophils displayed the same morphologic characteristics as peripheral blood basophils and differed ultrastructurally from mast cells in the same specimen. Large numbers of mast cells were occasionally seen in tumor tissue of patients with Hodgkin's disease. Many of the mast cells in Hodgkin's tumor revealed structural alteration of granules as well as evidence of degranulation when compared with mast cells in tumor-free lymph nodes of patients with Hodgkin's disease. These results indicate that basophils and mast cells may play a role in the inflammatory response in Hodgkin's disease.
在10例霍奇金病患者中的1例的肿瘤性淋巴结中，超微结构鉴定出大量嗜碱性粒细胞。组织嗜碱性粒细胞表现出与外周血嗜碱性粒细胞相同的形态学特征，并且在超微结构上与同一标本中的肥大细胞不同。在霍奇金病患者的肿瘤组织中偶尔可见大量肥大细胞。与霍奇金病患者无肿瘤的淋巴结中的肥大细胞相比，霍奇金肿瘤中的许多肥大细胞显示出颗粒的结构改变以及脱颗粒的证据。这些结果表明嗜碱性粒细胞和肥大细胞可能在霍奇金病的炎症反应中起作用。
