Michitaka K, Horiike N, Matsubara H, Masumoto T, Toshino A, Oka A, Ohoka H, Yokoyama M, Onji M
Third Department of Internal Medicine, Ehime University School of Medicine, Shigenobu-cho, Onsen-gun, 791-0295, Ehime-ken, Japan
Hepatol Res. 2000 Aug;18(2):122-131. doi: 10.1016/s1386-6346(99)00096-0.
To clarify the prevalence of TT virus (TTV) infection in renal transplant recipients and to estimate the role of TTV in patients with post-transplant liver function abnormalities, TTV-DNA of 47 renal transplant recipients was screened by polymerase chain reaction (PCR) according to a method described by Okamoto et al. before and after the renal transplantation. One of them was positive for hepatitis B surface antigen (HBsAg), one was positive for anti-hepatitis C virus (HCV) and other 45 were negative for both HBsAg and anti-HCV. TTV-DNA was detected in 22 of 47 patients before renal transplantation, and nine became positive after transplantation. All 47 patients showed a normal level of ALT before transplantation. Three of nine (33%) who became positive for TTV-DNA after transplantation and three of 16 (19%) who were negative for TTV-DNA before and after transplantation showed transient elevation of ALT. These results indicate that TTV was highly prevalent among renal transplant recipients, but a clear association between TTV and post-transplant liver function abnormality was not found.
为明确肾移植受者中TTV病毒（TTV）感染的患病率，并评估TTV在移植后肝功能异常患者中的作用，按照冈本等人描述的方法，采用聚合酶链反应（PCR）对47例肾移植受者肾移植前后的TTV-DNA进行筛查。其中1例乙肝表面抗原（HBsAg）阳性，1例抗丙型肝炎病毒（HCV）阳性，其他45例HBsAg和抗HCV均为阴性。47例患者肾移植前22例检测到TTV-DNA，移植后9例转为阳性。所有47例患者移植前ALT水平均正常。移植后TTV-DNA转为阳性的9例患者中有3例（33%），移植前后TTV-DNA均为阴性的16例患者中有3例（19%）出现ALT短暂升高。这些结果表明，TTV在肾移植受者中高度流行，但未发现TTV与移植后肝功能异常之间存在明确关联。
