Suda K, Nobukawa B, Yamasaki S, Suzuki F, Shimizu H, Takase M
Juntendo University School of Medicine, Department of Pathology 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Pathol Oncol Res. 2000;6(2):125-9. doi: 10.1007/BF03032362.
Eleven cases with mucinous noncystic carcinoma (MC) of the pancreas were studied by histology and mucin immunohistochemistry, to elucidate the mechanism, or route of development, and pre-existing histological type of MC of the pancreas. These MCs were observed in close approximation to, or surrounding, intraductal papillary-mucinous carcinomas (IPMCs), and were centrally situated among ductal adenocarcinomas (DAs). Hence, the 11 cases originated from 8 IPMCs and 3 DAs. The mechanism and routes to MC were divided into four types as follows: IPMC directly invaded the stroma (4 cases), over-production of mucin in IPMC expanded the branches of the pancreatic duct possibly resulting in rupture (3 cases), DA underwent extreme mucinous degeneration (3 cases), and a recurrent form, as MC, at the surgical stump of IPMC (one case). The outcomes of MC cases with IPMC had variable survival rates, while those from DA had short durations. MUC immunoreactivity in MC was divided into three categories; anti-MUC1-positive only (2 IPMCs, 2 DAs), mixed anti-MUC1 and anti-MUC2-positive (3 IPMCs, one DA) and anti-MUC-positive only (3 IPMCs). Pre-existing MC histological types included both IPMC and DA. These two pre-existing types of MC involved mucin overproduction and mucinous degeneration. MUC immunoreactivity in MC revealed three patterns, which may be related to variable outcomes.
对11例胰腺黏液性非囊性癌（MC）进行了组织学和黏液免疫组织化学研究，以阐明胰腺MC的发生机制、发展途径及先前存在的组织学类型。这些MC紧邻导管内乳头状黏液性癌（IPMC）或围绕其存在，并位于导管腺癌（DA）中央。因此，这11例病例起源于8例IPMC和3例DA。MC的发生机制和途径分为以下四种类型：IPMC直接侵犯间质（4例），IPMC中黏液过度产生使胰管分支扩张可能导致破裂（3例），DA发生极度黏液变性（3例），以及IPMC手术残端出现MC复发形式（1例）。起源于IPMC的MC病例生存率各异，而起源于DA的病例病程较短。MC中的MUC免疫反应性分为三类：仅抗MUC1阳性（2例IPMC，2例DA）、抗MUC1和抗MUC2混合阳性（3例IPMC，1例DA）以及仅抗MUC2阳性（3例IPMC）。先前存在的MC组织学类型包括IPMC和DA。这两种先前存在的MC类型均涉及黏液过度产生和黏液变性。MC中的MUC免疫反应性显示出三种模式，这可能与不同的预后相关。
