Suda K, Hirai S, Matsumoto Y, Mogaki M, Oyama T, Mitsui T, Fujibayashi M, Kumazawa K, Kajiwara T
Department of Pathology, Juntendo University, School of Medicine, Tokyo, Japan.
Am J Gastroenterol. 1996 Apr;91(4):798-800.
To investigate the histopathological and immunohistochemical features of intraductal "nodular" tumor located in the main pancreatic duct.
Four cases were studied, and the results were compared with those in 10 cases of common ductal adenocarcinomas of the pancreas.
The intraductal nodular carcinoma were large, more than 3 cm in diameter (range, 3-7 cm), lacked macroscopic mucin production, and presented a papillotubular adenocarcinoma. These tumors showed minimal invasion into the periductal tissue, duodenum, and choledochus. Immunohistochemically, the tumor cells were negative for anti-CEA and faintly positive for anti-CA19-9, in all except one tumor, whereas the common ductal adenocarcinomas were clearly positive for both. The postoperative course was favorable, and all three living patients remained healthy for more than 4 yr.
These tumors may be variants of intraductal tumors with a more favorable prognosis.
研究位于主胰管的导管内“结节状”肿瘤的组织病理学和免疫组化特征。
对4例病例进行研究，并将结果与10例胰腺普通导管腺癌的结果进行比较。
导管内结节状癌体积较大，直径超过3 cm（范围为3 - 7 cm），肉眼观察无黏液产生，表现为乳头管状腺癌。这些肿瘤对导管周围组织、十二指肠和胆总管的侵犯极小。免疫组化方面，除1例肿瘤外，肿瘤细胞抗CEA呈阴性，抗CA19 - 9呈弱阳性，而普通导管腺癌两者均呈明显阳性。术后病程良好，3例存活患者均健康存活超过4年。
这些肿瘤可能是预后较好的导管内肿瘤变体。
