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[肝紫癜病:鉴别诊断问题]

[Peliosis hepatis: problems of differential diagnosis].

作者信息

Leinung S, Gütz U, Stölzel U, Klengel S, Schwarze J

机构信息

Chirurgische Abteilung, Kreiskrankenhaus Oschatz gGmbH.

出版信息

Rontgenpraxis. 2000;52(9):295-301.

Abstract

Peliosis hepatis is a syndrome manly known to internists and pathologists. It is described as roundish blood cysts up to 1 cm large to the found in the hepatic parenchyma and correlated to the hepatic sinusoids. The pathogenesis is still unclear. The presumably essential disturbance of the structure of the reticular fibres is etiologically associated with anabolic and androgenic steroid therapy. Peliosis hepatis is pathognomonic for treatment with contraceptives and for severe chronic diseases, as tuberculosis or tumour. Little is known of therapeutic methods on the diagnostic of peliosis alterations in the liver. As peliosis-type hepatic lesions are apt to involution, it is generally recommended just to wait and see, with controlling examinations for imaging diagnostics. A case is described where a female patient, aged 42, otherwise healthy, came to see the doctor for obscure pain in the upper abdomen. Sonography of the upper abdomen indicated multiple lesions. The diagnostic method is described taking into account possible malign differential diagnoses or associated malign results which finally lead to partial resection of the liver.

摘要

肝紫癜是一种主要为内科医生和病理学家所熟知的综合征。它被描述为在肝实质中发现的直径达1厘米的圆形血囊肿,与肝血窦相关。其发病机制仍不清楚。网状纤维结构可能的主要紊乱在病因上与同化类固醇和雄激素治疗有关。肝紫癜是避孕药治疗和严重慢性疾病(如结核病或肿瘤)的特征性表现。对于肝脏中紫癜样改变的诊断,治疗方法知之甚少。由于紫癜型肝损伤易于消退,一般建议只是观察等待,并进行影像学诊断的对照检查。本文描述了一例病例,一名42岁、身体健康的女性患者因上腹部隐痛前来就诊。上腹部超声检查显示有多个病变。考虑到可能的恶性鉴别诊断或相关的恶性结果,描述了诊断方法,最终导致了肝脏部分切除术。

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