Dahl L K, Heine M
Circ Res. 1975 Jun;36(6):692-6. doi: 10.1161/01.res.36.6.692.
The genotype of homograft kidneys plays the primary role in determining chronic blood pressure levels in two strains of rats with opposite genetically controlled propensities for hyptertension. In hypertensive rats from the hypertension-prone (S) strain, a renal homograft from the same strain resulted in a slight rise in blood pressure to a level that was equivalent to that in appropriate uninephrectomized S controls. In contrast, a renal homograft from the hypertension-resistant (R) strain led to a sharp fall in blood pressure in hypertensive S recipients. Opposite results were found when the host came from the R strain: R homografts maintained the same low pressure as that seen in controls, whereas S homografts resulted in hypertension. We concluded that genetically controlled factors operating through the kidney can chronically modify the blood pressure up or down. The central role of the kidney in hypertension is thus further documented.
在具有相反遗传控制的高血压倾向的两种大鼠品系中，同种异体移植肾的基因型在决定慢性血压水平方面起主要作用。在高血压易感性（S）品系的高血压大鼠中，来自同品系的肾同种异体移植导致血压略有升高，达到与适当的单侧肾切除S对照相当的水平。相反，来自高血压抗性（R）品系的肾同种异体移植导致高血压S受体的血压急剧下降。当宿主来自R品系时发现了相反的结果：R同种异体移植维持与对照相同的低血压，而S同种异体移植导致高血压。我们得出结论，通过肾脏起作用的遗传控制因素可以长期上调或下调血压。因此，肾脏在高血压中的核心作用得到了进一步的证明。
