Maoz M, Neeman I
Department of Food Engineering and Biotechnology, Technion, 32000, Haifa, Israel.
J Ethnopharmacol. 2000 Aug;71(3):479-82. doi: 10.1016/s0378-8741(00)00187-2.
An antimycotic effect of an extract from Inula viscosa leaves was demonstrated affecting chitin synthesis in dermatophytes and Candida albicans. The antimycotic effect was compared to the effect caused by miconazole nitrate--an antifungal drug. The inhibition effect on chitin synthesis was not correlated to the extent of growth inhibition caused by the antifungal agents: both miconazole nitrate and the I. viscosa extract inhibited the growth of dermatophytes and C. albicans. Miconazole nitrate did not affect chitin synthesis--except for M. canis--whereas I. viscosa extract caused a significant decline in chitin content.
旋覆花叶片提取物对皮肤癣菌和白色念珠菌的几丁质合成有抗真菌作用。将该抗真菌作用与硝酸咪康唑（一种抗真菌药物）所产生的作用进行了比较。对几丁质合成的抑制作用与抗真菌剂所引起的生长抑制程度无关：硝酸咪康唑和旋覆花提取物均抑制皮肤癣菌和白色念珠菌的生长。硝酸咪康唑除对犬小孢子菌外不影响几丁质合成，而旋覆花提取物则使几丁质含量显著下降。
