The effects of sarin-like and soman-like organophosphorus agents on MAPK and JNK in rat brains.

作者信息

Niijima H, Nagao M, Nakajima M, Takatori T, Iwasa M, Maeno Y, Koyama H, Isobe I

机构信息

Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, 113-0033, Tokyo, Japan.

出版信息

Forensic Sci Int. 2000 Aug 14;112(2-3):171-8. doi: 10.1016/s0379-0738(00)00274-7.

One sarin-like and one soman-like organophosphorus agent [bis(isopropyl methyl)phosphonate, BIMP and bis(pinacolyl methyl)phosphonate, BPMP] were injected intravenously (iv) in rats. An increase in the tyrosine phosphorylation of several proteins in the cytosol fraction of the brain was observed. Activation of c-Jun N-terminal kinase (JNK) and slight activation of mitogen-activated protein kinase (MAPK) in the cytosol were also observed. The activation of these enzymes may be related to the high toxicity of these nerve agents.