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Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.

作者信息

Nicolaou KC, Baran PS, Zhong YL, Vega JA

机构信息

Department of Chemistry and The Skaggs Institute for Chemical Biology The Scripps Research Institute 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA).

出版信息

Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2525-2529.

PMID:10941125
Abstract
摘要

相似文献

1
Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.用于合成氨基糖及其文库的新型IBX介导方法 我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学方面提供的帮助，以及H. M. R. Hoffmann教授和A. Eschenmoser教授进行的有益讨论。我们还感谢这些实验室的Maria-Rosa Rodriguez博士和Keith Wilcoxen先生提供了通往9-12的早期中间体。这项工作得到了美国国立卫生研究院、斯卡格斯化学生物学研究所、西班牙教育和文化部（J.A.V.）和美国国家科学基金会（P.S.B）的资助，以及Array Biopharma、辉瑞、葛兰素威康、默克、先灵葆雅、霍夫曼-罗氏、勃林格殷格翰、杜邦和雅培实验室的拨款。
Angew Chem Int Ed Engl. 2000 Jul 17;39(14):2525-2529.
2
Rapid Access to Complex Molecular Architectures via o-Azaquinones We thank Dr. D. H. Huang, G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. This work was supported financially by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.S.B), and grants from ArrayBiopharma, Pfizer, Glaxo, Merck, Schering Plough, Hoffmann-La Roche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.
Angew Chem Int Ed Engl. 2001 Jun 1;40(11):2145-2149.
3
New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.含氮醌类化合物及其衍生物构建的新型合成技术：环氧喹诺霉素B的全合成 我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学分析方面提供的帮助。本研究得到了斯卡格斯化学生物学研究所、美国国立卫生研究院的资助，国家科学基金会提供的博士前奖学金（P.B.），以及雅培、安进、Array生物制药、勃林格殷格翰、葛兰素史克、霍夫曼 - 罗氏、杜邦、默克、诺华、辉瑞和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):207-210.
4
New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.含氮醌类及其衍生物构建的新合成技术：环氧喹诺霉素B的全合成 我们分别感谢D. H. Huang博士、G. Siuzdak博士和R. Chadha博士在核磁共振光谱、质谱和X射线晶体学分析方面提供的帮助。本研究得到了斯卡格斯化学生物学研究所、美国国立卫生研究院的资助，国家科学基金会为P.B.提供的博士前奖学金，以及雅培、安进、Array生物制药、勃林格殷格翰、葛兰素史克、霍夫曼-罗氏、杜邦、默克、诺华、辉瑞和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 May 4;40(9):1573.
5
Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems Professors M. G. Finn, A. Eschenmoser, and M. E. Newcomb are gratefully acknowledged for valuable discussions and suggestions. We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We would also like to thank Dr. G. Vasilikogiannakis for helpful discussions and an anonymous referee for critical suggestions. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), postdoctoral fellowships from ArrayBiopharma (N.Z.) and Bayer AG (R.K.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.高碘烷介导的酰苯胺及相关体系反应的机理研究 衷心感谢M. G. 芬恩教授、A. 埃申莫泽教授和M. E. 纽科姆教授进行的宝贵讨论并提出建议。我们分别感谢D. H. 黄博士和G. 苏兹达克博士在核磁共振光谱分析和质谱分析方面提供的帮助。我们还要感谢G. 瓦西利科贾纳基斯博士进行的有益讨论，以及一位匿名审稿人提出的批判性建议。这项工作得到了斯卡格斯化学生物学研究所、美国国立卫生研究院、美国国家科学基金会提供的博士前奖学金（P.B.）、ArrayBiopharma公司（N.Z.）和拜耳公司（R.K.）提供的博士后奖学金，以及雅培公司、安进公司、ArrayBiopharma公司、勃林格殷格翰公司、葛兰素公司、霍夫曼 - 罗氏公司、杜邦公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司提供的资助。
Angew Chem Int Ed Engl. 2001 Jan 5;40(1):202-206.
6
Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a pre-doctoral fellowship from Boehringer Ingelheim (Y.L.), a postdoctoral fellowship the George Hewitt Foundation (K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.凋亡诱导素的全合成：第1部分。逆合成分析与构建模块 我们分别感谢D. H. Huang博士和G. Siuzdak博士在核磁共振光谱和质谱分析方面提供的帮助。这项工作得到了美国国立卫生研究院、斯卡格斯化学生物学研究所、美国生物科学公司的资助，勃林格殷格翰公司提供的博士前奖学金（Y.L.）、乔治·休伊特基金会提供的博士后奖学金（K.C.F.），以及雅培实验室、Array生物制药公司、拜耳公司、勃林格殷格翰公司、杜邦公司、葛兰素公司、霍夫曼 - 罗氏公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司的资助。
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3849-3854.
7
Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2001 Oct 15;40(20):3854-3857.
8
Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.azaspiracid的FGHI环系统的合成 我们分别感谢D. H. Huang博士和G. Siuzdak博士在核磁共振光谱和质谱分析方面提供的帮助。这项工作得到了斯卡格斯化学生物学研究所、美国国立卫生研究院、百时美施贵宝公司提供的博士前奖学金（给F.B.）、芬兰科学院、埃拉和格奥尔格·埃尔恩罗思基金会、陶诺·滕宁基金会（均给P.M.P.）、ArrayBiopharma公司（新西兰）、拜耳公司（给N.D.）的博士后奖学金，以及雅培公司、安进公司、ArrayBiopharma公司、勃林格殷格翰公司、葛兰素公司、霍夫曼-罗氏公司、杜邦公司、默克公司、诺华公司、辉瑞公司和先灵葆雅公司提供的资助。
Angew Chem Int Ed Engl. 2001 Apr 1;40(7):1262-1265.
9
Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.
Angew Chem Int Ed Engl. 2001 May 4;40(9):1573.
10
Total Synthesis of Hybocarpone We thank Dr. D. H. Huang, Dr. G. Siuzdak and Dr. I. Ioannou for NMR spectroscopic, mass spectrometric and computational assistance, respectively. Financial support for this work was provided by the Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, CaPCURE, and Schering Plough.
Angew Chem Int Ed Engl. 2001 Feb 16;40(4):761-763.

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