Wlostowski T, Krasowska A, Godlewska-Zylkiewicz B
Institute of Biology, University of Bialystok, Poland.
J Trace Elem Med Biol. 2000 Jun;14(2):76-80. doi: 10.1016/S0946-672X(00)80033-4.
The effect of elevated levels of dietary cadmium on lipid peroxidation in the liver and kidneys of a small rodent, the bank vole, was determined in the present study. Males and females, aged 1 month, were given diets containing 0.40 and 80 mg Cd per kg; liver and kidneys were removed for TBA-RS as well as iron, copper, zinc, cadmium and metallothionein analyses at the end of 6 weeks. Dietary Cd significantly decreased the TBA-RS level in the liver and kidneys of both sexes; however, this effect appeared to be dose-dependent only for the male liver. The changes in hepatic and renal TBA-RS paralleled closely those of tissue iron. Copper concentration decreased significantly only in the male liver, while hepatic and renal zinc were not influenced by dietary Cd. The concentrations of Cd and metallothionein in the liver and kidneys increased significantly in a dose-dependent fashion. Regression analysis confirmed that TBA-RS in both organs correlated closely with iron. The data suggest that dietary Cd decreases hepatic and renal lipid peroxidation indirectly, through lowering the tissue iron concentration.
本研究测定了饮食中镉水平升高对一种小型啮齿动物——欧鼹肝脏和肾脏脂质过氧化的影响。选取1月龄的雄性和雌性欧鼹,给予每千克含0.40毫克和80毫克镉的饲料;6周结束时,取出肝脏和肾脏用于硫代巴比妥酸反应物(TBA-RS)以及铁、铜、锌、镉和金属硫蛋白的分析。饮食中的镉显著降低了雌雄两性肝脏和肾脏中的TBA-RS水平;然而,这种影响似乎仅在雄性肝脏中呈剂量依赖性。肝脏和肾脏中TBA-RS的变化与组织铁的变化密切平行。仅雄性肝脏中的铜浓度显著降低,而肝脏和肾脏中的锌不受饮食中镉的影响。肝脏和肾脏中镉和金属硫蛋白的浓度呈剂量依赖性显著增加。回归分析证实,两个器官中的TBA-RS与铁密切相关。数据表明,饮食中的镉通过降低组织铁浓度间接降低肝脏和肾脏的脂质过氧化。