Yasumizu T, Okuno T, Fukada Y, Hoshi K
Department of Obstetrics and Gynecology, Yamanashi Medical University, Tamaho, Japan.
Endocr J. 2000 Apr;47(2):103-9. doi: 10.1507/endocrj.47.103.
The purpose of this cross-sectional study was to characterize the age-related change in bone metabolism during the pre- and postmenopausal periods, and to define the standard levels of three serum markers of bone metabolism, pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), carboxyterminal propeptide of type I procollagen (PICP), and bone gla protein (BGP), in Japanese adult women. The bone mineral density (BMD) of the lumbar spine (L2-L4) and the serum levels of ICTP, PICP and BGP were determined in a total of 207 healthy Japanese women (108 premenopausal and 99 postmenopausal). The lumbar BMD decreased significantly with increasing age not only in postmenopausal women (P<0.001) but also in premenopausal women (P=0.014). There was a clear gap in the serum levels of ICTP, PICP and BGP between the premenopausal and postmenopausal group (P<0.001), but those were absolutely the same within each group except for ICTP in the postmenopausal women. These findings and the values of serum ICTP, PICP and BGP in pre- and postmenopausal women obtained in this study are expected to be very useful for treatment of postmenopausal osteoporosis.
这项横断面研究的目的是描述绝经前后骨代谢的年龄相关变化，并确定日本成年女性骨代谢的三种血清标志物——I型胶原吡啶啉交联羧基末端肽（ICTP）、I型前胶原羧基末端前肽（PICP）和骨钙素（BGP）的标准水平。对总共207名健康日本女性（108名绝经前女性和99名绝经后女性）测定了腰椎（L2-L4）的骨密度（BMD）以及ICTP、PICP和BGP的血清水平。腰椎骨密度不仅在绝经后女性中随年龄增长显著降低（P<0.001），在绝经前女性中也如此（P=0.014）。绝经前和绝经后组之间ICTP、PICP和BGP的血清水平存在明显差异（P<0.001），但除绝经后女性的ICTP外，每组内这些标志物的水平完全相同。本研究中获得的这些发现以及绝经前和绝经后女性血清ICTP、PICP和BGP的值预计对绝经后骨质疏松症的治疗非常有用。
