Yasumizu T, Hoshi K, Iijima S, Asaka A
Department of Obstetrics and Gynecology, Yamanashi Medical University, Japan.
Endocr J. 1998 Feb;45(1):45-51. doi: 10.1507/endocrj.45.45.
To reassess the clinical utility of serum pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP), a promising but controversial indicator of bone resorption, we evaluated its performance as a biochemical marker in a 6-month study of a strictly selected population of 76 Japanese postmenopausal and healthy women, 33 recipients of hormone replacement therapy and 43 nonrecipients. We measured bone mineral density (BMD) of the lumbar spine (L2-L4), and serum ICTP, carboxyterminal propeptide of type I procollagen (PICP) and other conventional serum biochemical markers, e.g. bone gla protein (BGP), alkaline phosphatase, calcium and phosphate at the entry and 6 months later. We calculated the percent change between the baseline and 6-month values (delta%) in lumbar BMD and the biochemical markers, individually, and compared the degree of correlations between delta% in BMD and that in the biochemical markers. Delta% in ICTP and delta% in BGP correlated with delta% in BMD negatively and significantly. Especially delta% in ICTP correlated with that in BMD to a high degree (P<0.0001). No significant correlation was observed in other biochemical markers. We concluded that serum ICTP is a sensitive and useful bone resorption marker in the postmenopausal population, which strongly correlates with the change in BMD.
为了重新评估血清I型胶原吡啶啉交联羧基末端肽（ICTP）作为一种有前景但存在争议的骨吸收指标的临床实用性，我们在一项为期6个月的研究中，对76名严格筛选的日本绝经后健康女性进行了评估，其中33名接受激素替代疗法，43名未接受。我们测量了她们腰椎（L2-L4）的骨密度（BMD），以及血清ICTP、I型前胶原羧基末端前肽（PICP）和其他传统血清生化指标，如骨钙素（BGP）、碱性磷酸酶、钙和磷，在入组时和6个月后进行测量。我们分别计算了腰椎BMD和生化指标在基线和6个月时的变化百分比（delta%），并比较了BMD的delta%与生化指标的delta%之间的相关程度。ICTP的delta%和BGP的delta%与BMD的delta%呈显著负相关。尤其是ICTP的delta%与BMD的delta%高度相关（P<0.0001）。在其他生化指标中未观察到显著相关性。我们得出结论，血清ICTP是绝经后人群中一种敏感且有用的骨吸收标志物，与BMD的变化密切相关。
