Fritsche K L, Anderson M, Feng C
Department of Animal Sciences and the Graduate Nutritional Sciences Program, University of Missouri, Columbia, MO 65211, USA.
J Infect Dis. 2000 Sep;182 Suppl 1:S54-61. doi: 10.1086/315925.
In mice, individual dietary omega-3 polyunsaturated fatty acids n-3 (PUFA) were found to be sufficient to effect the changes in circulating interleukin (IL)-12 and interferon (IFN)-gamma levels that were previously seen in fish oil-fed mice. Weanling female C3H mice were fed one of five experimental diets. All five diets met all known nutritional requirements for mice and differed only in the fat source. After 4 weeks, mice were challenged with live Listeria monocytogenes or sterile PBS. Twenty-four hours after infection, n-3 PUFA-fed mice had significantly lower circulating IL-12 p70 and IFN-gamma than mice fed the control diet (P<.01). In addition, splenic cytokine mRNA for IL-12 p40, tumor necrosis factor-alpha, and IL-1beta were lower in infected mice fed n-3 PUFA-containing diets than in mice fed the olive oil ethyl esters control diet. The reduction of IL-12 and IFN-gamma production by n-3 PUFA may have important implications for host infectious disease resistance.
在小鼠中，发现单独的膳食ω-3多不饱和脂肪酸n-3（PUFA）足以引起循环白细胞介素（IL）-12和干扰素（IFN）-γ水平的变化，这些变化先前在喂食鱼油的小鼠中可见。将断奶的雌性C3H小鼠喂食五种实验饮食之一。所有五种饮食均满足小鼠所有已知的营养需求，仅脂肪来源不同。4周后，用活的单核细胞增生李斯特菌或无菌磷酸盐缓冲盐水攻击小鼠。感染后24小时，喂食n-3 PUFA的小鼠循环中的IL-12 p70和IFN-γ明显低于喂食对照饮食的小鼠（P<0.01）。此外，喂食含n-3 PUFA饮食的感染小鼠脾脏中IL-12 p40、肿瘤坏死因子-α和IL-1β的细胞因子mRNA低于喂食橄榄油乙酯对照饮食的小鼠。n-3 PUFA对IL-12和IFN-γ产生的降低可能对宿主抗感染疾病具有重要意义。
