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The role of immunostimulatory CpG-DNA in septic shock.

作者信息

Wagner H, Lipford G B, Häcker H

机构信息

Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Germany.

出版信息

Springer Semin Immunopathol. 2000;22(1-2):167-71. doi: 10.1007/s002810000023.

DOI:10.1007/s002810000023
PMID:10944811
Abstract
摘要

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本文引用的文献

1
Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins.细菌CpG-DNA在体内激活树突状细胞:对可溶性蛋白的不依赖辅助性T细胞的细胞毒性T细胞应答。
Eur J Immunol. 2000 Dec;30(12):3591-7. doi: 10.1002/1521-4141(200012)30:12<3591::AID-IMMU3591>3.0.CO;2-J.
2
Cell type-specific activation of mitogen-activated protein kinases by CpG-DNA controls interleukin-12 release from antigen-presenting cells.CpG-DNA介导的丝裂原活化蛋白激酶的细胞类型特异性激活可控制抗原呈递细胞释放白细胞介素-12。
EMBO J. 1999 Dec 15;18(24):6973-82. doi: 10.1093/emboj/18.24.6973.
3
Bacterial CpG DNA activates immune cells to signal infectious danger.
JAK激酶是细菌RNA和聚肌苷酸:聚胞苷酸诱导PKR酪氨酸磷酸化所必需的。
Int J Clin Exp Med. 2013;6(1):16-25. Epub 2012 Nov 18.
4
The role of immunostimulatory nucleic acids in septic shock.免疫刺激核酸在脓毒性休克中的作用。
Int J Clin Exp Med. 2012;5(1):1-23. Epub 2012 Jan 15.
5
Optimized systemic dosing with CpG DNA enhances dendritic cell-mediated rejection of a poorly immunogenic mammary tumor in BALB/c mice.CpG DNA 的优化全身给药增强了 BALB/c 小鼠中树突状细胞介导的对低免疫原性乳腺肿瘤的排斥反应。
Clin Transl Sci. 2009 Feb;2(1):62-6. doi: 10.1111/j.1752-8062.2008.00073.x.
6
Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.不同的合成核苷酸基序识别模式:具有独特细胞因子诱导谱的强效免疫调节寡脱氧核糖核苷酸制剂的设计与开发。
Nucleic Acids Res. 2003 May 1;31(9):2393-400. doi: 10.1093/nar/gkg343.
细菌CpG DNA激活免疫细胞以发出感染危险信号。
Adv Immunol. 1999;73:329-68. doi: 10.1016/s0065-2776(08)60790-7.
4
Phylogenetic perspectives in innate immunity.固有免疫中的系统发育观点。
Science. 1999 May 21;284(5418):1313-8. doi: 10.1126/science.284.5418.1313.
5
Bacterial DNA as immune cell activator.细菌DNA作为免疫细胞激活剂。
Trends Microbiol. 1998 Dec;6(12):496-500. doi: 10.1016/s0966-842x(98)01408-5.
6
CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation.抗原呈递细胞的CpG-DNA特异性激活需要应激激酶活性,且在此之前会发生非特异性内吞作用和内体成熟。
EMBO J. 1998 Nov 2;17(21):6230-40. doi: 10.1093/emboj/17.21.6230.
7
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells.细菌DNA和免疫刺激型CpG寡核苷酸可触发小鼠树突状细胞的成熟和激活。
Eur J Immunol. 1998 Jun;28(6):2045-54. doi: 10.1002/(SICI)1521-4141(199806)28:06<2045::AID-IMMU2045>3.0.CO;2-8.
8
DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen.DNA作为佐剂:昆虫DNA和合成寡脱氧核苷酸增强T细胞对特定抗原反应的能力。
J Exp Med. 1998 Apr 6;187(7):1145-50. doi: 10.1084/jem.187.7.1145.
9
Innate immunity: the virtues of a nonclonal system of recognition.固有免疫:非克隆识别系统的优势
Cell. 1997 Oct 31;91(3):295-8. doi: 10.1016/s0092-8674(00)80412-2.
10
Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock.巨噬细胞通过DNA基序感知病原体:诱导肿瘤坏死因子-α介导的休克。
Eur J Immunol. 1997 Jul;27(7):1671-9. doi: 10.1002/eji.1830270712.