Nilsson G
Acta Physiol Scand. 1975 Dec;95(4):477-81. doi: 10.1111/j.1748-1716.1975.tb10077.x.
Dogs were provided with mucosal septal pouches of the stomach and of the duodenal bulb. In some dogs a drainage gastric cannula was inserted into the most dependent portion of the stomach. In dogs which were found to secrete acid spontaneously during a control period at the start of each experiment, the bulbar puches were perfused with 0.1 M HC1 for 5-120 min. Bulbar acidification rapidly and profoundly reduced the basal acid output. In dogs which did not secrete acid spontaneously during the control periodbulbar pouches were perfused with 0.1 M HC1 for 1 h. Bulbar acidification did not significantly influence the plasma gastrin concentration and no acid was secreted from the Pavlov pouches following such acidification. The present results support the hypothesis that reduction of the intrabulbar pH may contribute to the reduction of acid secretion during interdigestive periods. The physiological significance of of mechanisms in the upper intestine which induce acid secretion following a reduction of the intraluminal pH is questioned.
给狗制作胃黏膜隔袋和十二指肠球部黏膜隔袋。在一些狗身上，将引流胃插管插入胃的最下垂部位。在每个实验开始时的对照期发现能自发分泌胃酸的狗中，用0.1M盐酸灌注十二指肠球部袋5至120分钟。十二指肠球部酸化迅速且显著降低基础胃酸分泌量。在对照期不自发分泌胃酸的狗中，用0.1M盐酸灌注十二指肠球部袋1小时。十二指肠球部酸化对血浆胃泌素浓度无显著影响，酸化后巴甫洛夫袋也不分泌胃酸。目前的结果支持这样的假说，即十二指肠球部pH值降低可能有助于消化间期胃酸分泌减少。十二指肠球部腔内pH值降低后诱导胃酸分泌的上消化道机制的生理意义受到质疑。
