Nilsson G
Acta Physiol Scand. 1975 Nov;95(3):258-62. doi: 10.1111/j.1748-1716.1975.tb10049.x.
Dogs were provided with mucosal septal pouches of the fundic stomach and of the duodenal bulb. Gastric secretion was stimulated by intravenous infusion of submaximal doses of porcine gastrin or the stable choline ester Urecholine. Acid perfusion of bulbar pouches profoundly inhibited acid responses to gastrin. Bulbar acidification produced little or no reduction in acid secretion induced by Urecholine. Small doses of Urecholine do not release gastrin in the dog but may induce acid secretion, mainly by direct cholinergic stimulation of the HCl glands. The fact that Urecholine-induced acid secretion was not inhibited in the present experiments is consistent with the hypothesis that the bulbar mechanism does not interfere with cholinergic stimulation acting on the parietal cells.
给狗制备胃底和十二指肠球部的黏膜隔袋。通过静脉输注次最大剂量的猪胃泌素或稳定的胆碱酯类乌拉胆碱来刺激胃液分泌。十二指肠球部隔袋的酸灌注可显著抑制对胃泌素的酸反应。球部酸化对乌拉胆碱诱导的酸分泌几乎没有或没有降低作用。小剂量的乌拉胆碱不会在狗体内释放胃泌素，但可能主要通过对盐酸分泌腺的直接胆碱能刺激来诱导酸分泌。在本实验中乌拉胆碱诱导的酸分泌未受抑制这一事实与以下假设一致，即球部机制不会干扰作用于壁细胞的胆碱能刺激。
