Weiss M, Bänziger O, Neff T, Fanconi S
Department of Pediatric Anesthesia, University Children's Hospital, Zurich, Switzerland.
Intensive Care Med. 2000 Jun;26(6):776-9. doi: 10.1007/s001340051246.
To determine whether infusion line compliance contributes to irregular drug delivery during vertical displacement of syringe pumps.
Five different commercially available infusion lines were studied at infusion rates of 0.5, 1.0, and 1.5 ml/h. Zero drug delivery time was measured after acute line loop formation (70 cm) using an electronic balance. Compliance of each infusion line was calculated using a pressure transducer and measurement of the occlusion release bolus at 300 mmHg occlusion pressure. Finally, the influence of infusion line compliance on drug delivery during acute lowering of the syringe pump was studied using low- and high-compliance infusion lines.
Acute line loop formation resulted in zero drug delivery time from 5.1 +/- 1.5 to 44.0 +/- 6.8 s at flow rates of 0.5 ml/h. Increased flow rates significantly reduced loop-induced flow variability. A close correlation was found between zero drug delivery time and calculated infusion line compliance at 0.5 ml/h (linear regression R2 = 0.79). Lowering of the syringe pump 50 cm prolonged zero drug delivery time from 295.8 +/- 20.7 s with the low-compliance tube to 463.3 +/- 24.0 s with the high-compliance infusion line.
Infusion line compliance contributes to irregular drug delivery associated with vertical displacement of syringe pumps. Siphoning of the infusion line during patient care should be avoided, and flow rates of 1 ml/h or higher are recommended. Low-compliance infusion lines are indicated whenever highly short-acting vasoactive drugs at low delivery rates are administered.
确定输液管顺应性是否会导致注射泵垂直移动期间药物输送不规律。
研究了五种不同的市售输液管，输液速率分别为0.5、1.0和1.5 ml/h。使用电子天平在急性形成输液管环路（70 cm）后测量零药物输送时间。使用压力传感器并测量在300 mmHg闭塞压力下的闭塞释放推注量来计算每个输液管的顺应性。最后，使用低顺应性和高顺应性输液管研究了注射泵急性下降期间输液管顺应性对药物输送的影响。
在0.5 ml/h的流速下，急性形成输液管环路导致零药物输送时间从5.1±1.5秒增加到44.0±6.8秒。流速增加显著降低了环路引起的流量变异性。发现在0.5 ml/h时零药物输送时间与计算出的输液管顺应性之间存在密切相关性（线性回归R2 = 0.79）。将注射泵降低50 cm使零药物输送时间从低顺应性管的295.8±20.7秒延长至高顺应性输液管的463.3±24.0秒。
输液管顺应性会导致与注射泵垂直移动相关的药物输送不规律。应避免在患者护理期间输液管虹吸现象，建议流速为1 ml/h或更高。当以低输送速率使用高度短效血管活性药物时，应使用低顺应性输液管。
