Muotoe-Okafor F A, Gugnani H C, Gugnani A, Okafor G
Department of Microbiology, University of Nigeria, Nsukka, Nigeria.
Mycoses. 2000;43(5):173-5. doi: 10.1046/j.1439-0507.2000.00568.x.
Serum samples from 60 subjects with confirmed HIV-1 infection including 28 AIDS patients and 32 carriers were examined by immunodiffusion for precipitating antibodies to antigens of Histoplasma, Blastomyces and Candida. Seven of the subjects, four patients and three carriers, showed antibodies to histoplasmin prepared from mycelial cultural filtrate of Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii although without any clinical signs of classical or African histoplasmosis. Another eight subjects comprising five patients and three carriers demonstrated antibodies to yeast cell antigen of Candida albicans; three of the patients had oral lesions clinically suggestive of Candida infection. None of the serum samples revealed antibodies to "A" antigen (yeast cell antigen) of Blastomyces dermatitidis.
对60名确诊为HIV-1感染的受试者的血清样本进行了免疫扩散检测，这些受试者包括28名艾滋病患者和32名携带者，检测针对组织胞浆菌、芽生菌和念珠菌抗原的沉淀抗体。7名受试者，4名患者和3名携带者，显示出针对由荚膜组织胞浆菌变种荚膜组织胞浆菌和荚膜组织胞浆菌变种杜波依斯菌丝体培养滤液制备的组织胞浆菌素的抗体，尽管没有任何经典或非洲组织胞浆菌病的临床症状。另外8名受试者，包括5名患者和3名携带者，显示出针对白色念珠菌酵母细胞抗原的抗体；其中3名患者有临床上提示念珠菌感染的口腔病变。没有一份血清样本显示出针对皮炎芽生菌“A”抗原（酵母细胞抗原）的抗体。
