Hong Y, Rice T, Gagnon J, Pérusse L, Province M, Bouchard C, Leon A S, Skinner J S, Wilmore J H, Rao D C, Després J P
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Med Sci Sports Exerc. 2000 Aug;32(8):1438-44. doi: 10.1097/00005768-200008000-00012.
The main purpose of the present investigation was to test whether and to what extent familial/genetic factors are involved in the changes of postheparin lipoprotein lipase (deltaPH-LPL) activity and triglyceride (deltaTG) levels in response to exercise training. Additional hypotheses were also tested as to whether there were familial/genetic factors shared by baseline and the corresponding response to exercise training (i.e., by baseline triglyceride (TG(B)) and deltaTG and by baseline postheparin lipoprotein lipase (PH-LPL(B)) and deltaPH-LPL activity).
Serum TG and PH-LPL were measured in 459 subjects from 99 sedentary Caucasian families of the HERITAGE Family study before (baseline) and after completing a 20 wk (3 times per week) exercise training protocol. The training protocol had a target intensity of 75% of the heart rate associated with baseline VO2max during the last 6 wk. PH-LPL activity was measured in the study subjects. Both univariate and bivariate familial correlation analyses were applied to the baseline and response data.
The maximal heritabilities for deltaTG and deltaPH-LPL activity were 22% and 15%, respectively. There were no common familial factors for TG(B) and deltaTG, nor were there any for PH-LPL(B) and deltaPH-LPL. However, we found that there were common familial factors underlying deltaTG and deltaPH-LPL; these familial factors seemed to differ across sex and generation groups.
Although there were no common familial factors underlying the covariation between the baseline triglyceride and PH-LPL activity and the corresponding responses to exercise training (i.e., TG(B) with deltaTG or PH-LPL(B) with deltaPH-LPL), the deltaTG and deltaPH-LPL covariation apparently share some common familial determinants.
本研究的主要目的是测试家族/遗传因素是否以及在多大程度上参与了运动训练后肝素后脂蛋白脂肪酶（ΔPH-LPL）活性和甘油三酯（ΔTG）水平的变化。还对其他假设进行了测试，即基线和运动训练相应反应（即基线甘油三酯（TG(B)）与ΔTG，以及基线肝素后脂蛋白脂肪酶（PH-LPL(B)）与ΔPH-LPL活性）之间是否存在共同的家族/遗传因素。
在HERITAGE家族研究的99个久坐不动的白种人家庭的459名受试者中，在完成一项为期20周（每周3次）的运动训练方案之前（基线）和之后，测量血清TG和PH-LPL。训练方案的目标强度为最后6周期间与基线最大摄氧量相关心率的75%。在研究对象中测量PH-LPL活性。对基线和反应数据进行单变量和双变量家族相关性分析。
ΔTG和ΔPH-LPL活性的最大遗传率分别为22%和15%。TG(B)与ΔTG之间没有共同的家族因素，PH-LPL(B)与ΔPH-LPL之间也没有。然而，我们发现ΔTG和ΔPH-LPL存在共同的家族因素；这些家族因素在性别和代际组之间似乎有所不同。
尽管基线甘油三酯和PH-LPL活性之间的协变以及运动训练的相应反应（即TG(B)与ΔTG或PH-LPL(B)与ΔPH-LPL）之间没有共同的家族因素，但ΔTG和ΔPH-LPL的协变显然共享一些共同的家族决定因素。
