Nikkilä E A, Huttunen J K, Ehnholm C
Metabolism. 1977 Feb;26(2):179-86. doi: 10.1016/0026-0495(77)90053-1.
The lipoprotein lipase (LPL) and hepatic triglyceride lipase (HL) activities of postheparin plasma were determined by a specific immunochemical method in 17 patients with primary hyperlipoproteinemia before and during treatment with clofibrate. The drug caused a significant reduction of serum cholesterol (11%) and triglyceride (45%) levels. Postheparin plasma LPL activity rose in all subjects, the average change being 46% (p less than 0.001). The increase of LPL was positively correlated to the pretreatment LPL activity. There was no correlation between the serum triglyceride concentration and postheparin LPL activity either before or during clofibrate administration. On the other hand, in the clofibrate responders there was a weak correlation between the relative changes of triglyceride concentration and LPL activity (r = 0.43, p less than 0.05). During clofibrate treatment the LPL activity of the hypertriglyceridemic patients was significantly higher than the corresponding value of untreated healthy normoglyceridemic subjects of similar age. The postheparin plasma HL activity was not influenced by clofibrate.
采用特异性免疫化学方法，测定了17例原发性高脂血症患者在服用氯贝丁酯治疗前及治疗期间肝素后血浆中的脂蛋白脂肪酶（LPL）和肝甘油三酯脂肪酶（HL）活性。该药使血清胆固醇水平显著降低（11%），甘油三酯水平显著降低（45%）。所有受试者肝素后血浆LPL活性均升高，平均变化为46%（p<0.001）。LPL的升高与治疗前LPL活性呈正相关。在服用氯贝丁酯之前或期间，血清甘油三酯浓度与肝素后LPL活性之间均无相关性。另一方面，在氯贝丁酯反应者中，甘油三酯浓度的相对变化与LPL活性之间存在弱相关性（r = 0.43，p<0.05）。在氯贝丁酯治疗期间，高甘油三酯血症患者的LPL活性显著高于年龄相仿、未经治疗的健康正常甘油三酯血症受试者的相应值。肝素后血浆HL活性不受氯贝丁酯影响。
