自然杀伤细胞与病毒相关癌症。
NK cells and virus-related cancers.
作者信息
Mishra Rabinarayan, Welsh Raymond, Szomolanyi-Tsuda Eva
机构信息
Department of Pathology, University of Massachusetts Medical School, 368 Plantation Street, AS9-2051, Worcester, MA 01605.
出版信息
Crit Rev Oncog. 2014;19(1-2):107-19. doi: 10.1615/critrevoncog.2014010866.
Abstract
Natural killer (NK) cells become activated during viral infections and can play roles in such infections by attacking virus-infected cells or by regulating adaptive immune responses. Experimental models suggest that NK cells may also have the capacity to restrain virus-induced cancers. Here, we discuss the seven viruses linked to human cancers and the evidence of NK cell involvement in these systems.
摘要
自然杀伤（NK）细胞在病毒感染期间被激活，并可通过攻击病毒感染细胞或调节适应性免疫反应在这类感染中发挥作用。实验模型表明，NK细胞可能也有抑制病毒诱导癌症的能力。在此，我们讨论与人类癌症相关的七种病毒以及NK细胞参与这些系统的证据。
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