Inkovaara J, Heikinheimo R, Jarvinen K, Kasurinen U, Hanhijarvi H, Iisalo E
Br Med J. 1975 Jul 12;3(5975):73-4. doi: 10.1136/bmj.3.5975.73.
In a double-blind trial with monofluorophosphate (25 mg fluoride per day) given to 460 aged persons (237 treated, 233 control) for eight months no difference was observed in height, admission to hospital, or mortality. Fractures and exacerbation of arthrosis were more frequent in the fluoride group. Vertebral x-ray films showed no difference. The free ionized fluoride levels in the plasma of the fluoride-treated group were still twice as high two months after treatment ended. Fluoride treatment in the prophylaxis of osteoporosis is not recommended unless there is simultaneous measurement of plasma ionized fluoride levels.
在一项双盲试验中，给460名老年人（237人接受治疗，233人作为对照）每日服用单氟磷酸酯（每日含氟25毫克），为期8个月，结果发现身高、住院率或死亡率方面均无差异。氟化物组的骨折和关节病加重情况更为常见。脊椎X光片显示无差异。治疗结束两个月后，接受氟化物治疗组血浆中的游离离子氟水平仍高出两倍。除非同时测量血浆离子氟水平，否则不建议采用氟化物治疗来预防骨质疏松症。
