Abou-Madi M, Keszler H, Yacoub O
Can Anaesth Soc J. 1975 May;22(3):316-29. doi: 10.1007/BF03004841.
A technique of nebulizing lidocaine in the upper airways was developed and its effectiveness in preventing cardiovascular responses to laryngoscopy and intubation was documented. In ten pre-treated patients the average percentage-rise in systolic blood pressure was 10.3 per cent and there were no arrhythmias. The pulse rate increased by 16.8 per cent. In ten control patients, the systolic blood pressure increased by 56 per cent and the incidence of arrhythmias was 40 per cent. The pulse rate increased by 38.8 per cent. The significance and application of these results is discussed and compared to other available methods. The opinion is expressed that the effect of the aerosol, especially as it relates to the suppression of arrhythmias, is partly due to systemic absorption of lidocaine.
一种在上呼吸道雾化利多卡因的技术得以开发，并记录了其在预防喉镜检查和插管引起的心血管反应方面的有效性。在10例经过预处理的患者中，收缩压平均升高百分比为10.3%，且无心律失常发生。脉搏率增加了16.8%。在10例对照患者中，收缩压升高了56%，心律失常发生率为40%。脉搏率增加了38.8%。讨论了这些结果的意义和应用，并与其他可用方法进行了比较。有人认为气雾剂的作用，尤其是与心律失常抑制相关的作用，部分归因于利多卡因的全身吸收。
