Ryhänen P, Saarela E, Saukkonen J, Hollmén A
Ann Chir Gynaecol. 1977;66(6):294-8.
The effect of small intravenous doses of practolol (0.2 mg/kg body weight) on the circulatory response to laryngoscopy and endotracheal intubation, when administered with atropine (0.01 mg/kg b.w.) prior to anaesthesia was studied in 39 patients with and without cardiovascular disease. Practolol diminished significantly the rise of mean arterial pressure and pulse rate affected by laryngoscopy and endotracheal intubation when performed under thiopentone-succinylcholine anaesthesia. Arrhythmias were also less frequent through the statistical significance could not be ascertained in this small series. The small practolol dose used had no adverse circulatory effects. It is suggested that the administration of a small prophylactic dose of practolol is useful in preventing the excessive cardiovascular response due to laryngoscopy and endotracheal intubation.
在39例有或无心血管疾病的患者中，研究了麻醉前静脉注射小剂量心得宁（0.2毫克/千克体重）并同时给予阿托品（0.01毫克/千克体重）时，其对喉镜检查和气管插管循环反应的影响。在硫喷妥钠-琥珀酰胆碱麻醉下进行喉镜检查和气管插管时，心得宁能显著减轻平均动脉压和心率的升高。心律失常的发生率也较低，尽管在这个小样本系列中无法确定其统计学意义。所使用的小剂量心得宁没有不良循环影响。建议预防性给予小剂量心得宁有助于预防喉镜检查和气管插管引起的过度心血管反应。
