侵袭性肺炎球菌疾病的结局：一项基于英国的研究。牛津肺炎球菌监测小组。
Outcome of invasive pneumococcal disease: a UK based study. Oxford Pneumococcal Surveillance Group.
作者信息
Shackley F, Knox K, Morris J B, Crook D, Griffiths D, Mayon-White R, George R, Willocks L, Moxon E
机构信息
Oxford Vaccine Group, University of Oxford, UK.
出版信息
Arch Dis Child. 2000 Sep;83(3):231-3. doi: 10.1136/adc.83.3.231.
Abstract
METHODS
The records of 106 children aged less than 5 years with invasive disease caused by Streptococcus pneumoniae were reviewed.
RESULTS
The clinical manifestations were meningitis (37%), upper respiratory tract infection (24%), pneumonia (19%), and occult bacteraemia (18%). One child died and seven had persisting neurological impairment. Five serotypes caused 83% of disease and 92% of the serotypes are included in the seven valent conjugate vaccines which are undergoing trials.
CONCLUSIONS
These data suggest that S pneumoniae infection is associated with a low case fatality rate but substantial morbidity in the UK.
摘要
方法
回顾了106例5岁以下由肺炎链球菌引起侵袭性疾病的儿童记录。
结果
临床表现为脑膜炎（37%）、上呼吸道感染（24%）、肺炎（19%）和隐匿性菌血症（18%）。1名儿童死亡，7名有持续性神经功能损害。5种血清型导致83%的疾病，92%的血清型包含在正在进行试验的七价结合疫苗中。
结论
这些数据表明，在英国肺炎链球菌感染病死率低但发病率高。
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