Colman G, Cooke E M, Cookson B D, Cooper P G, Efstratiou A, George R C
Division of Hospital and Respiratory Infection, Central Public Health Laboratory, London.
J Med Microbiol. 1998 Jan;47(1):17-27. doi: 10.1099/00222615-47-1-17.
A total of 5348 isolates of Streptococcus pneumoniae was serotyped and screened for insusceptibility to tetracycline, penicillin, erythromycin and chloramphenicol. Of these, 4238 (79%) were isolated from patients who had pneumonia or meningitis or were bacteraemic. Altogether, 3948 (74%) of the isolates belonged to one or other of the serotypes 1, 3, 4, 6, 8, 9, 14, 19 or 23 with serotypes 6, 14, 18, 19 and 23 being frequent causes of invasive disease in young children. Many isolates of type 1 were isolated from pneumonia and few from meningitis. Some 768 (14%) isolates were insusceptible to one or more antibiotic and 591 of these belonged to serotypes 6, 9, 14, 19 or 23. Representatives of type 14 resistant to erythromycin were prominent from 1986 onwards. There was an increase in the number of multi-resistant pneumococci from 1985. Among these were isolates of type 23 insusceptible to penicillin, chloramphenicol and tetracycline and cultures of type 6 resistant additionally to erythromycin.
共对5348株肺炎链球菌进行了血清分型，并筛查了它们对四环素、青霉素、红霉素和氯霉素的耐药性。其中，4238株（79%）分离自患有肺炎、脑膜炎或菌血症的患者。总体而言，3948株（74%）分离株属于血清型1、3、4、6、8、9、14、19或23中的一种，血清型6、14、18、19和23是幼儿侵袭性疾病的常见病因。血清型1的许多分离株分离自肺炎患者，而分离自脑膜炎患者的较少。约768株（14%）分离株对一种或多种抗生素耐药，其中591株属于血清型6、9、14、19或23。从1986年起，血清型14中对红霉素耐药的菌株较为突出。自1985年以来，多重耐药肺炎球菌的数量有所增加。其中包括对青霉素、氯霉素和四环素耐药的血清型23分离株，以及对红霉素也耐药的血清型6培养物。
