囊性纤维化患者的草酸盐和钙排泄情况
Oxalate and calcium excretion in cystic fibrosis.
作者信息
Turner M A, Goldwater D, David T J
机构信息
University Department of Child Health, Booth Hall Children's Hospital, Charlestown Road, Blackley, Manchester M9 7AA, UK.
出版信息
Arch Dis Child. 2000 Sep;83(3):244-7. doi: 10.1136/adc.83.3.244.
BACKGROUND
A patient with cystic fibrosis (CF) and repeated calcium oxalate renal stones prompted us to investigate other children for risk factors for this recognised complication of CF.
METHODS
Twenty four hour urinary excretion of calcium, oxalate, and glycolate was measured in children with CF and no symptoms of renal tract stones. Normal diet and treatments were continued.
RESULTS
In 26 children (aged 5-15.9 years) oxalate excretion was correlated with age; 14 of 26 children had oxalate excretion above an age appropriate normal range. There was a positive correlation between oxalate excretion and glycolate excretion. Mean calcium excretion was 0.06 mmol/kg/24 h with 21 of 24 children having calcium excretion below the normal range.
CONCLUSIONS
Hyperoxaluria may reflect malabsorption although correlation between excretion of oxalate and glycolate suggests a portion of the excess oxalate is derived from metabolic processes. The hypocalciuria observed here may protect children with CF from renal stones.
背景
一名患有囊性纤维化（CF）且反复出现草酸钙肾结石的患者促使我们对其他儿童进行调查，以寻找CF这种公认并发症的危险因素。
方法
对无尿路结石症状的CF儿童测量24小时尿钙、草酸和乙醇酸排泄量。继续正常饮食和治疗。
结果
在26名儿童（年龄5 - 15.9岁）中，草酸排泄量与年龄相关；26名儿童中有14名的草酸排泄量高于相应年龄的正常范围。草酸排泄量与乙醇酸排泄量呈正相关。平均钙排泄量为0.06 mmol/kg/24小时，24名儿童中有21名的钙排泄量低于正常范围。
结论
高草酸尿症可能反映吸收不良，尽管草酸和乙醇酸排泄之间的相关性表明部分过量草酸源自代谢过程。此处观察到的低钙尿症可能使CF儿童免受肾结石困扰。
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