Carmichael L E, Medic B L, Bistner S I, Aguirre G D
Cornell Vet. 1975 Jul;65(3):331-51.
Canine adenovirus-type 1 (CAV-1)-antibody complexes caused severe anterior uveitis with corneal edema ("blue eye") when injected into the anterior chamber of normal dogs. The response of the anterior uvea to such immune complexes (IC) was similar to the spontaneously occurring disease. In the presence of complement (C'), IC caused release of neutrophile chemotactic factors. Following phagocytosis of IC-C' leukocytes released lysosomal enzymes, as indicated by the presence of acid phosphatase in the surrounding medium. Membrane bound viral aggregates, presumably IC, were common in neutrophiles and in macrophages that had infiltrated the anterior chamber of opaque eyes that occurred after intravenous (IV) inoculation with attenuated CAV-1. These data were incorporated into a postulated scheme for the pathogenesis of CAV-1 uveitis with corneal edema.
将犬1型腺病毒（CAV-1）抗体复合物注入正常犬的前房时，会引发伴有角膜水肿的严重前葡萄膜炎（“蓝眼”）。前葡萄膜对这种免疫复合物（IC）的反应与自然发生的疾病相似。在补体（C'）存在的情况下，IC会导致嗜中性粒细胞趋化因子的释放。如周围介质中存在酸性磷酸酶所示，IC-C'被白细胞吞噬后会释放溶酶体酶。静脉注射减毒CAV-1后出现的不透明眼前房中，嗜中性粒细胞和巨噬细胞中常见膜结合病毒聚集体，推测为IC。这些数据被纳入了CAV-1角膜水肿性葡萄膜炎发病机制的假设方案中。
