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Obesity and insulin resistance.

作者信息

Kahn B B, Flier J S

机构信息

Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

出版信息

J Clin Invest. 2000 Aug;106(4):473-81. doi: 10.1172/JCI10842.

DOI:10.1172/JCI10842
PMID:10953022
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC380258/
Abstract
摘要

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本文引用的文献

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Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus.
Trends Endocrinol Metab. 1996 Nov;7(9):311-9. doi: 10.1016/s1043-2760(96)00154-3.
2
Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists.过氧化物酶体增殖物激活受体γ激动剂治疗胰岛素抵抗
J Clin Invest. 2000 Aug;106(4):467-72. doi: 10.1172/JCI10843.
3
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice.蛋白酪氨酸磷酸酶1B缺陷小鼠的能量消耗增加、肥胖减轻及组织特异性胰岛素敏感性增强。
Mol Cell Biol. 2000 Aug;20(15):5479-89. doi: 10.1128/MCB.20.15.5479-5489.2000.
4
In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin.瘦素的体内给药直接激活胰岛素敏感组织中的信号转导：与胰岛素的途径重叠但不同。
Endocrinology. 2000 Jul;141(7):2328-39. doi: 10.1210/endo.141.7.7536.
5
Obesity in the new millennium.新千年的肥胖问题。
Nature. 2000 Apr 6;404(6778):632-4. doi: 10.1038/35007504.
6
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice.脂肪组织的手术植入可逆转脂肪萎缩性小鼠的糖尿病。
J Clin Invest. 2000 Feb;105(3):271-8. doi: 10.1172/JCI7901.
7
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein.蛋白酪氨酸磷酸酶1B介导的酪氨酸去磷酸化及胰岛素受体底物-1的失活。与Grb2衔接蛋白形成三元复合物可能会促进此过程。
J Biol Chem. 2000 Feb 11;275(6):4283-9. doi: 10.1074/jbc.275.6.4283.
8
Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes.胰岛素可选择性增加链脲佐菌素诱导糖尿病大鼠肝脏中SREBP-1c mRNA的水平。
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13656-61. doi: 10.1073/pnas.96.24.13656.
9
Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling.叉头转录因子：对蛋白激酶B（c-akt）信号传导的新见解。
J Mol Med (Berl). 1999 Sep;77(9):656-65. doi: 10.1007/s001099900050.
10
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes.固醇调节元件结合蛋白-1c是胰岛素作用于肝脏中葡萄糖激酶和脂肪生成相关基因表达的主要介质。
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12737-42. doi: 10.1073/pnas.96.22.12737.