Mao Qingsong, Liu Nianzhou, Xiong Tian, Wang Xinyi, Tian Xinling, Kong Yuzhe
Hepatobiliary Pancreatic Surgery, Banan Hospital Affiliated of Chongqing Medical University, Chongqing, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2025 Aug 22;16:1562135. doi: 10.3389/fendo.2025.1562135. eCollection 2025.
The association of the triglyceride glucose (TyG) index and related TyG metrics with obesity indices has been demonstrated to correlate with the incidence of cardiovascular disease (CVD). Nonetheless, this relationship has not been thoroughly investigated in patients with cardiovascular-kidney-metabolic (CKM) syndrome stages 0-3.
This study involved 7364 participants from the China Health and Retirement Longitudinal Study (CHARLS). Cox risk regression and restricted cubic spline (RCS) regression were used to analyze the correlation between the TyG index and related TyG indicators and the incidence rate of cardiovascular disease. To compare predictive performance, time-dependent Harrell's C-indices, net reclassification index and integrated discrimination improvement were conducted.
Research shows that the TyG index and all TyG-related indexes can predict the incidence rate of CVD. RCS regression analysis showed that all indicators were linearly related to the incidence rate of CVD. The linear relationship between TyG and waist circumference (TyG-WC) or waist-to-height ratio (TyG-WHtR) still exists in CKM stages 1, 2, and 3. Compared with the TyG index (C-index: 0.611, p<0.001) and TyG-BMI (C-coefficient: 0.616, p<0.001), TyG-WC (C-index: 0.621, p<0.001) and TyG-WHtR (C-index: 0.621, p<0.001) have better effects on predicting the incidence rate of CVD.
Both the TyG index and the TyG-related index are independent predictors of the incidence rate of CVD in patients with CKM syndrome stage 0-3. Importantly, TyG-WC and TyG-WHtR have a better predictive effect.
甘油三酯葡萄糖（TyG）指数及相关TyG指标与肥胖指数的关联已被证明与心血管疾病（CVD）的发病率相关。然而，这种关系在心血管-肾脏-代谢（CKM）综合征0-3期患者中尚未得到充分研究。
本研究纳入了来自中国健康与养老追踪调查（CHARLS）的7364名参与者。采用Cox风险回归和受限立方样条（RCS）回归分析TyG指数及相关TyG指标与心血管疾病发病率之间的相关性。为比较预测性能，进行了时间依赖性Harrell's C指数、净重新分类指数和综合判别改善分析。
研究表明，TyG指数和所有与TyG相关的指标都可以预测CVD的发病率。RCS回归分析表明，所有指标与CVD发病率均呈线性相关。在CKM 1、2和3期，TyG与腰围（TyG-WC）或腰高比（TyG-WHtR）之间的线性关系仍然存在。与TyG指数（C指数：0.611，p<0.001）和TyG-BMI（C系数：0.616，p<0.001）相比，TyG-WC（C指数：0.621，p<0.001）和TyG-WHtR（C指数：0.621，p<0.001）对预测CVD发病率的效果更好。
TyG指数和与TyG相关的指数都是CKM综合征0-3期患者CVD发病率的独立预测因素。重要的是，TyG-WC和TyG-WHtR具有更好的预测效果。
