Carroll J D, Maclay W P
Curr Med Res Opin. 1975;3(2):68-71. doi: 10.1185/03007997509113649.
Pizotifen, an antaminic, was investigated in a double-blind placebo controlled trial to evaluate its efficacy in migraine prophylaxis. It was found to be and effective prophylactic in a proportion of migraine patients, reducing the frequency as well as the severity of headaches. Some patients showed weight gain. Several patients have continued treatment for up to 2 years with good control of their migraine and a reduction in the amount of medicament required for the acute attack.
苯噻啶，一种抗组胺药，在一项双盲安慰剂对照试验中进行了研究，以评估其预防偏头痛的疗效。结果发现，它对一部分偏头痛患者是一种有效的预防药物，可减少头痛的频率和严重程度。一些患者出现体重增加。几名患者持续治疗长达2年，偏头痛得到良好控制，急性发作所需药物量减少。
