Vilming S, Standnes B, Hedman C
Cephalalgia. 1985 Mar;5(1):17-23. doi: 10.1046/j.1468-2982.1985.0501017.x.
The prophylactic anti-migraine effect of the serotonin antagonist pizotifen and the beta 1-selective beta-adrenoceptor antagonist metoprolol was compared in a double-blind cross-over study. The dosage of pizotifen was 0.5 mg t.i.d. and that of metoprolol 50 mg b.i.d. Thirty-five patients with classical or common migraine were included in the investigation. Five patients withdrew during the course of the study; four because of side effects (three on pizotifen, one on metoprolol) and one because of unassociated illness. The results show that there was no statistically significant difference in efficacy between metoprolol and pizotifen. The tolerance, especially regarding weight gain, was the major drawback with pizotifen, while metoprolol was generally well tolerated.
在一项双盲交叉研究中，比较了血清素拮抗剂苯噻啶和β1选择性β肾上腺素能受体拮抗剂美托洛尔的预防性抗偏头痛作用。苯噻啶的剂量为0.5毫克，每日三次，美托洛尔的剂量为50毫克，每日两次。35例典型或普通偏头痛患者纳入研究。5例患者在研究过程中退出；4例因副作用（3例服用苯噻啶，1例服用美托洛尔），1例因无关疾病。结果表明，美托洛尔和苯噻啶在疗效上无统计学显著差异。耐受性，尤其是体重增加方面，是苯噻啶的主要缺点，而美托洛尔一般耐受性良好。
