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[儿童炎症性肠病]

[Inflammatory bowel disease in children].

作者信息

Perisić V

机构信息

Univerzitetska decja klinika, Beograd.

出版信息

Acta Chir Iugosl. 2000;47(1-2):57-9.

PMID:10953367
Abstract

Beside Crohn's disease (CD) and ulcerative colitis (UC), paediatric chronic inflammatory bowel diseases encompass variety of different inflammatory conditions: allergic colitis in infancy, colitis of hypereosinophilic syndrome, Behcet colitis, microscopic colitides etc. Paediatric CD characterises predominance of inflammatory and obstructive disease variant. Because of their growth suppression an early introduction of azathioprine in steroid dependent and steroid refractory cases is frequently indicated. In teenage period resection procedures may be an elective and initial therapeutic option due to necessity of proper pubertal mental and physical development. Paediatric UC frequently manifests initially as pancolitis what indicates higher rate of colectomy rate. Therapy is still dispute about an optimal surgical procedure: restorative proctocolectomy or ileo-anal pull through techniques. Allergic colitis in infancy may mimic ulcerative colitis and rises a possibility of diagnostic and therapeutic confusions. Its treatment is strictly nutritive.

摘要

除了克罗恩病(CD)和溃疡性结肠炎(UC)外,儿童慢性炎症性肠病还包括多种不同的炎症性病症:婴儿过敏性结肠炎、高嗜酸性粒细胞综合征结肠炎、白塞氏结肠炎、显微镜下结肠炎等。儿童CD的特征是炎症性和阻塞性疾病变体占主导。由于其生长抑制作用,对于依赖类固醇和对类固醇难治的病例,经常需要早期使用硫唑嘌呤。在青少年时期,由于青春期身心正常发育的需要,手术切除可能是一种选择性的初始治疗选择。儿童UC最初常表现为全结肠炎,这表明结肠切除术的发生率较高。关于最佳手术方法,即恢复性直肠结肠切除术或回肠肛管拖出术,治疗仍存在争议。婴儿过敏性结肠炎可能会模仿溃疡性结肠炎,并增加诊断和治疗混淆的可能性。其治疗严格来说是营养性的。

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