Uijtdehaage S H, Thayer J F
Department of Psychiatry and Behavioral Sciences, University of California, Los Angeles, USA.
Clin Auton Res. 2000 Jun;10(3):107-10. doi: 10.1007/BF02278013.
Invasive animal models indicate that the accelerative effects of the sympathetic nervous system on heart rate are highly dependent on the background level of vagal activity. A noninvasive, parasympathetic chronotropic index (respiratory sinus arrhythmia) and a sympathetic chronotropic index (left ventricular ejection time) were used to evaluate autonomic control of human heart rate. A strong interaction, previously called accentuated antagonism, was found. Sympathetic heart rate effects were substantially smaller with high levels of vagal tone than with low vagal background activity. Furthermore, vagal effects became progressively stronger with increasing sympathetic background activity, demonstrating the predominance of parasympathetic control of human heart rate. This finding implies that changes in cardiac activity resulting from changes in sympathetic control cannot be interpreted accurately unless concurrent vagal activity is taken into account, as well.
侵入性动物模型表明，交感神经系统对心率的加速作用高度依赖于迷走神经活动的背景水平。使用一种非侵入性的副交感神经变时指数（呼吸性窦性心律不齐）和一种交感神经变时指数（左心室射血时间）来评估人类心率的自主控制。发现了一种强烈的相互作用，以前称为增强拮抗作用。与低迷走神经背景活动相比，高迷走神经张力时交感神经对心率的影响要小得多。此外，随着交感神经背景活动的增加，迷走神经的影响逐渐增强，这表明副交感神经对人类心率的控制占主导地位。这一发现意味着，除非同时考虑迷走神经活动，否则不能准确解释交感神经控制变化引起的心脏活动变化。
