检测和定量流感患者外周血中对一种新的主要组织相容性复合体II类限制性甲型流感病毒基质蛋白表位具有特异性的CD4(+) T细胞。
Detection and quantification of CD4(+) T cells with specificity for a new major histocompatibility complex class II-restricted influenza A virus matrix protein epitope in peripheral blood of influenza patients.
作者信息
Linnemann T, Jung G, Walden P
机构信息
Department of Dermatology and Allergy, Charité, Medical School of the Humboldt University, D-10089 Berlin, Germany.
出版信息
J Virol. 2000 Sep;74(18):8740-3. doi: 10.1128/jvi.74.18.8740-8743.2000.
Abstract
FVFTLTVPS was identified as the core sequence of a new major histocompatibility complex class II-restricted T-cell epitope of influenza virus matrix protein. Epitope-specific CD4(+) T cells were detected in the peripheral blood of patients with frequencies of up to 0.94%, depending on the number of additional terminal amino acids.
摘要
FVFTLTVPS被鉴定为流感病毒基质蛋白新的主要组织相容性复合体II类限制性T细胞表位的核心序列。根据额外末端氨基酸的数量，在患者外周血中检测到表位特异性CD4(+) T细胞，频率高达0.94%。
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