Mills K M, Kheifets L I, Nelson L M, Bloch D A, Takemoto-Hambleton R, Kelsey J L
Division of Epidemiology, Stanford University, Palo Alto, CA, USA.
Epidemiology. 2000 Sep;11(5):581-8. doi: 10.1097/00001648-200009000-00015.
Exposure assessment presents a major challenge for studies evaluating the association between household exposure to electric and magnetic fields and adverse health outcomes, especially the reliance on proxy respondents when study subjects themselves have died. We evaluated the reliability of proxy- and self-reported household appliance exposure. We recruited 92 healthy couples through either random-digit dialing or newspaper advertisements. Trained interviewers administered questionnaires to each member of a couple independently to assess the reliability of proxy-reported household appliance use. Eighty-five couples completed a second interview 2 months later to assess the reliability of self-reported appliance use. Reliability of proxy-reported appliance exposure was good when we inquired about having any exposure to each of the eight indicator appliances during the past year (range of kappa coefficients = 0.63-0.85; median = 0.76) but was lower with increased time to recall or increased detail. Reliability of self respondents reporting 2 months apart was excellent (range of kappa coefficients = 0.75-0.94; median = 0.87) for having any exposure to the eight indicator appliances during the past year, but reliability was again lower with increased detail. When we used self reports at the first interview as the standard, little systematic over- or underreporting occurred for proxy respondents or for self respondents reporting 2 months later. Because this study did not include cases of specific disease, these findings of no systematic differences in reporting do not refer to case or control status. In summary, reliability of self respondents' reports of appliance use is very good for recent time periods and good for broad aspects of exposure in distant time periods. Proxy respondents can provide information regarding broad aspects of appliance exposure in the past year, but detailed aspects of exposure or exposure in more distant time periods is not reliable.
暴露评估对于评估家庭暴露于电场和磁场与不良健康结果之间关联的研究而言是一项重大挑战,尤其是当研究对象已经死亡,需要依靠代理受访者的情况。我们评估了代理报告和自我报告的家用电器暴露情况的可靠性。我们通过随机数字拨号或报纸广告招募了92对健康夫妇。经过培训的访谈员分别向每对夫妇的成员发放问卷,以评估代理报告的家用电器使用情况的可靠性。85对夫妇在2个月后完成了第二次访谈,以评估自我报告的电器使用情况的可靠性。当我们询问过去一年中是否接触过八种指示电器中的每一种时,代理报告的电器暴露情况的可靠性良好(卡帕系数范围=0.63-0.85;中位数=0.76),但随着回忆时间的增加或细节的增多,可靠性会降低。对于过去一年中是否接触过八种指示电器,间隔2个月的自我受访者报告的可靠性极佳(卡帕系数范围=0.75-0.94;中位数=0.87),但随着细节的增加,可靠性同样会降低。当我们将第一次访谈中的自我报告作为标准时,代理受访者或2个月后进行报告的自我受访者几乎没有出现系统性的高估或低估情况。由于本研究未包括特定疾病的病例,这些报告中无系统性差异的发现并不涉及病例或对照状态。总之,自我受访者关于电器使用的报告在近期的可靠性非常好,在远期暴露的广泛方面也较好。代理受访者可以提供过去一年中电器暴露广泛方面的信息,但暴露的详细方面或更远期的暴露情况不可靠。