Schneider-Kolsky M, D'Antona D, Evans L W, Taylor N, O'Connor A, Groome N P, de Kretser D, Wallace E M
Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
BJOG. 2000 Aug;107(8):995-1000. doi: 10.1111/j.1471-0528.2000.tb10402.x.
To examine changes in maternal serum levels of activin A and follistatin during pregnancy and labour.
In three cross sectional and three longitudinal studies venous blood was collected from women during pregnancy, spontaneous labour, labour induction and prior to elective caesarean section for the measurement of activin A and follistatin.
Monash Medical Centre, Clayton, Victoria, Australia.
One hundred and twenty-three women participated in a cross sectional study in pregnancy, 18 women in two longitudinal pregnancy studies, 36 women in a cross sectional labour study, nine women in a longitudinal study of labour induction. Ten women undergoing elective caesarean section were also studied.
Activin A and follistatin were measured using two sensitive and specific enzyme-linked immunosorbent assays.
In the cross sectional study of pregnancy, mean (SEM) maternal serum activin A and follistatin levels increased towards term (2.4 ng/mL (0.3) and 1.8 ng/mL (0.3) in first trimester to 18.9 ng/mL (3.8) and 5.3 ng/mL (0.9) at term, respectively), but the longitudinal study revealed that levels plateau in the last three weeks of pregnancy (16.0 ng/mL (2.6) and 6.2 ng/mL (1.4) at 37 weeks and 16.6 ng/mL (3.5) and 6.2 ng/mL (0.5) before labour for activin A and follistatin, respectively). There was no difference in levels of activin A and follistatin between women delivered by caesarean section and labouring women at term (14.9 ng/mL (2.8) vs 11.0 ng/mL (0.93) and 5.95 ng/mL (0.67) vs 5.71 ng/mL (0.63), respectively) and levels of both proteins did not alter throughout spontaneous or induced labour.
We believe that these data argue against activin A playing an acute role in the initiation or regulation of human parturition.
研究孕期及分娩过程中母体血清中激活素A和卵泡抑素水平的变化。
在三项横断面研究和三项纵向研究中，于孕期、自然分娩、引产及择期剖宫产术前采集女性静脉血，以测定激活素A和卵泡抑素。
澳大利亚维多利亚州克莱顿市莫纳什医疗中心。
123名女性参与了孕期横断面研究，18名女性参与了两项孕期纵向研究，36名女性参与了分娩横断面研究，9名女性参与了引产纵向研究。还对10名接受择期剖宫产的女性进行了研究。
采用两种灵敏且特异的酶联免疫吸附测定法测定激活素A和卵泡抑素。
在孕期横断面研究中，母体血清激活素A和卵泡抑素的平均（标准误）水平随孕周增加而升高（孕早期分别为2.4 ng/mL（0.3）和1.8 ng/mL（0.3），足月时分别为18.9 ng/mL（3.8）和5.3 ng/mL（0.9）），但纵向研究显示，孕期最后三周水平趋于平稳（37周时激活素A和卵泡抑素分别为16.0 ng/mL（2.6）和6.2 ng/mL（1.4），临产前分别为及16.6 ng/mL（3.5）和6.2 ng/mL（0.5））。剖宫产分娩的女性与足月分娩的女性相比，激活素A和卵泡抑素水平无差异（分别为14.9 ng/mL（2.8）对11.0 ng/mL（0.93）以及5.95 ng/mL（0.67）对5.71 ng/mL（0.63）），且两种蛋白水平在自然分娩或引产过程中均未改变。
我们认为，这些数据表明激活素A在人类分娩的启动或调节中不发挥急性作用。
