Fowler P A, Evans L W, Groome N P, Templeton A, Knight P G
Department of Obstetrics and Gynaecology, University of Aberdeen, UK.
Hum Reprod. 1998 Dec;13(12):3530-6. doi: 10.1093/humrep/13.12.3530.
Maternal serum concentrations of inhibin-A, inhibin-B, activin-A, activin-AB, pro-alphaC-related inhibin forms, total follistatin, steroids and gonadotrophins were measured longitudinally in six normal singleton pregnancies. Maternal venous blood was collected randomly during a spontaneous follicular phase prior to donor insemination, at 5, 7, 9, 11, 16, 20, 24, 28, 32 and 36 weeks after the first missed menses and in the early puerperium. Steroid and gonadotrophin profiles conformed to previous reports. While at week 5 of gestation inhibin-A, activin-A and follistatin concentrations were similar to those at the follicular phase, all three increased progressively (P < 0.001) to maximal concentrations in week 36: approximately 48-fold (3740 +/- 1349 ng inhibin-A/ml), approximately 22-fold (6109 +/- 1443 ng activin-A/ml) and approximately 10-fold (3563 +/- 418 ng follistatin/ml) higher. Pro-alphaC concentrations reached a maximum in weeks 5 (approximately 5-fold, P < 0.001) and 36 (1027 +/- 174 pg/ml, P < 0.01). Inhibin-B (71 +/- 23 pg/ml prior to pregnancy) was undetectable (<12 pg/ml) between week 5-16 of gestation but increased slightly in the third trimester (26 +/- 7 pg/ml in week 36). Activin-AB was undetectable throughout pregnancy. Post-partum concentrations of inhibin-A (41 +/- 12 ng/ml), inhibin-B (<12 pg/ml), activin-A (950 +/- 149 pg/ml), pro-alphaC (128 +/- 22 pg/ml) and follistatin (990 +/- 79 ng/ml) were substantially lower than at week 36 of gestation. The activin-A:follistatin ratio increased from 0.5 in week 5 to 1.8 in week 36, suggesting that more free activin-A is available in the maternal circulation during late pregnancy.
在6例正常单胎妊娠中，纵向测定了母体血清中抑制素A、抑制素B、激活素A、激活素AB、前αC相关抑制素形式、总卵泡抑素、类固醇和促性腺激素的浓度。在供精人工授精前的自发卵泡期、首次月经推迟后的第5、7、9、11、16、20、24、28、32和36周以及产褥早期随机采集母体静脉血。类固醇和促性腺激素谱与先前报道一致。妊娠第5周时，抑制素A、激活素A和卵泡抑素浓度与卵泡期相似，但三者均逐渐升高（P<0.001），在第36周达到最高浓度：分别约为卵泡期的48倍（3740±1349 ng抑制素A/ml）、22倍（6109±1443 ng激活素A/ml）和10倍（3563±418 ng卵泡抑素/ml）。前αC浓度在第5周（约5倍，P<0.001）和第36周（1027±174 pg/ml，P<0.01）达到峰值。抑制素B（妊娠前为71±23 pg/ml）在妊娠第5至16周不可检测（<12 pg/ml），但在妊娠晚期略有升高（第36周为26±7 pg/ml）。激活素AB在整个孕期均不可检测。产后抑制素A（41±12 ng/ml）、抑制素B（<12 pg/ml）、激活素A（950±149 pg/ml）、前αC（128±22 pg/ml）和卵泡抑素（990±79 ng/ml）的浓度显著低于妊娠第36周。激活素A与卵泡抑素的比值从第5周的0.5增加到第36周的1.8，表明妊娠晚期母体循环中可利用的游离激活素A更多。
