血清抑制素B与不孕女性的排卵成功相关。
Serum inhibin B correlates with successful ovulation in infertile women.
作者信息
Luisi S, Palumbo M, Calonaci G, De Leo V, Razzi S, Inaudi P, Cobellis G, Petraglia F
机构信息
Department of Pediatric, Obstetric and Reproductive Medicine, Chair of Obstetric and Gynecology, University of Siena, 53100 Siena, Italy.
出版信息
J Assist Reprod Genet. 2003 Jun;20(6):241-7. doi: 10.1023/a:1024111629191.
PURPOSE
To investigate whether inhibin B and activin A serum and follicular fluid levels in infertile women undergoing induction of superovulation correlate with successful ovulation.
METHODS
Infertile women (n = 16) (30-43 years of age) undergoing induction of superovulation for assisted reproduction were studied. A blood sample was collected before and days 3, 8, and 12 during the induction of superovulation. A follicular fluid sample at the time of ovarian pick up was also collected. Serum and follicular fluid were assayed for inhibin B, activin A, and estradiol.
RESULTS
According to the successful follicular development women were divided in two groups: (A) responders (n = 10) and (B) poor responders (n = 6). Women of group A showed mean follicular fluid inhibin B levels higher than in group B (P = 0.001), while no significant difference for activin A levels was found. During induction of superovulation serum activin A levels did not change in both groups of women, while inhibin B and estradiol levels significantly increase only in responder women (P < 0.001). Serum inhibin B and estradiol levels correlated with follicles developed > or = 10 mm (P = 0.000).
CONCLUSIONS
Serum inhibin B is an effective marker of follicular development in infertile women undergoing induction of superovulation, and may represent a further marker for ovarian follicular capacity.
目的
研究接受超促排卵的不孕女性血清及卵泡液中抑制素B和激活素A水平与排卵成功是否相关。
方法
对16名（年龄30 - 43岁）接受辅助生殖超促排卵的不孕女性进行研究。在超促排卵诱导前及诱导过程中的第3、8和12天采集血样。同时在取卵时采集卵泡液样本。检测血清和卵泡液中的抑制素B、激活素A和雌二醇。
结果
根据卵泡发育成功情况将女性分为两组：（A）反应者（n = 10）和（B）反应不良者（n = 6）。A组女性的平均卵泡液抑制素B水平高于B组（P = 0.001），而激活素A水平未发现显著差异。在超促排卵诱导过程中，两组女性的血清激活素A水平均未改变，而抑制素B和雌二醇水平仅在反应者女性中显著升高（P < 0.001）。血清抑制素B和雌二醇水平与发育至≥10 mm的卵泡相关（P = 0.000）。
结论
血清抑制素B是接受超促排卵的不孕女性卵泡发育的有效标志物，可能代表卵巢卵泡功能的另一标志物。
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