Janssen A M, Bosman C B, van Duijn W, Oostendorp-van de Ruit M M, Kubben F J, Griffioen G, Lamers C B, van Krieken J H, van de Velde C J, Verspaget H W
Department of Gastroenterology, Leiden University Medical Center, the Netherlands.
Clin Cancer Res. 2000 Aug;6(8):3183-92.
The oxidant-antioxidant balance is thought to be important in the initiation, promotion, and therapy resistance of cancer. In the present study, we assessed the expression of the antioxidants manganese superoxide dismutase (Mn-SOD) and copper/zinc superoxide dismutase in gastric and esophageal carcinomas and their relation with clinical outcome. Adenocarcinomas of the stomach (n = 81) as well as squamous cell carcinomas of the esophagus (n = 10) showed an enhanced immunohistochemical expression of Mn-SOD, which was accompanied by a significantly higher tissue level (P < or = 0.007) compared with their corresponding normal mucosa. In contrast, copper/zinc superoxide dismutase was found to be marginally lower in these malignant tissues in comparison with the normal tissues. The superoxide dismutase levels were not found to be associated with major clinicopathological features of the gastric cancer patients. Univariate analysis revealed, however, that a high Mn-SOD level in gastric carcinomas, a low level in the normal gastric mucosa, and a high ratio of these two levels in gastric cancer patients are indicative of a poor overall survival. Multivariate analysis, including all clinicopathological parameters, revealed that the Mn-SOD ratio in particular is an independent prognostic parameter in gastric cancer patients.
氧化还原平衡被认为在癌症的起始、进展和治疗抵抗中起着重要作用。在本研究中，我们评估了抗氧化剂锰超氧化物歧化酶（Mn-SOD）和铜/锌超氧化物歧化酶在胃癌和食管癌中的表达及其与临床结局的关系。胃癌腺癌（n = 81）以及食管鳞状细胞癌（n = 10）显示Mn-SOD的免疫组化表达增强，与相应的正常黏膜相比，其组织水平显著更高（P≤0.007）。相比之下，发现这些恶性组织中的铜/锌超氧化物歧化酶略低于正常组织。未发现超氧化物歧化酶水平与胃癌患者的主要临床病理特征相关。然而，单因素分析显示，胃癌中Mn-SOD水平高、正常胃黏膜中水平低以及胃癌患者中这两个水平的高比值表明总体生存率较差。多因素分析包括所有临床病理参数，结果显示Mn-SOD比值尤其是胃癌患者的独立预后参数。
