Wei Yuxun, Li Hong, Li Yue, Zeng Yue, Quan Tian, Leng Yanen, Chang En, Bai Yingtao, Bian Yuan, Hou Yi
Pharmacy Department, Clinical Trial Institution, The People's Hospital of Zhongjiang, Deyang, China.
West China School of Medicine, Sichuan University, Chengdu, China.
Front Pharmacol. 2024 Nov 1;15:1496661. doi: 10.3389/fphar.2024.1496661. eCollection 2024.
In recent years, researchers have highly observed that neurological disorders (NSDs) with the aging of the population are a global health burden whose prevalence is increasing every year. Previous evidence suggested that the occurrence of neurological disorders is correlated with predisposing factors such as inflammation, aging, and injury. Particularly, the neuronal cells are susceptible to oxidative stress, leading to lesions caused by high oxygen-consuming properties. Oxidative stress (OS) is a state of peroxidation, which occurs as a result of the disruption of the balance between oxidizing and antioxidizing substances. The oxidative intermediates such as free radicals, hydrogen peroxide (HO), and superoxide anion (O-) produced by OS promote disease progression. Curcumin, a natural diketone derived from turmeric, is a natural antioxidant with a wide range of neuroprotective, anti-inflammatory, anti-tumor, anti-aging, and antioxidant effects. Fortunately, curcumin is recognized for its potent antioxidant properties and is considered a promising candidate for the prevention and treatment of neurological diseases. Consequently, this review elucidates the mechanisms by which curcumin mitigates oxidative stress and emphasizes the potential in treating nervous system disorders, including depression, Alzheimer's disease, Parkinson's disease, epilepsy, subarachnoid hemorrhage, and glioblastoma. We aim to provide a new therapeutic option for the management of neurological diseases.
近年来，研究人员高度关注到，随着人口老龄化，神经系统疾病已成为一项全球性的健康负担，其患病率逐年上升。先前的证据表明，神经系统疾病的发生与炎症、衰老和损伤等诱发因素相关。特别是，神经元细胞易受氧化应激影响，因其高耗氧特性而导致损伤。氧化应激（OS）是一种过氧化状态，是氧化物质与抗氧化物质之间平衡被打破的结果。由氧化应激产生的自由基、过氧化氢（HO）和超氧阴离子（O-）等氧化中间体促进疾病进展。姜黄素是一种从姜黄中提取的天然二酮，是一种具有广泛神经保护、抗炎、抗肿瘤、抗衰老和抗氧化作用的天然抗氧化剂。幸运的是，姜黄素因其强大的抗氧化特性而受到认可，被认为是预防和治疗神经系统疾病的有前景的候选药物。因此，本综述阐述了姜黄素减轻氧化应激的机制，并强调其在治疗包括抑郁症、阿尔茨海默病、帕金森病、癫痫、蛛网膜下腔出血和胶质母细胞瘤在内的神经系统疾病方面的潜力。我们旨在为神经系统疾病的治疗提供一种新的治疗选择。
