Janssen A M, Bosman C B, Sier C F, Griffioen G, Kubben F J, Lamers C B, van Krieken J H, van de Velde C J, Verspaget H W
Department of Gastroenterology and Hepatology, Leiden University Medical Center, The Netherlands.
Br J Cancer. 1998 Oct;78(8):1051-7. doi: 10.1038/bjc.1998.626.
Reactive oxygen metabolites are implicated in the initiation and promotion of cancer. In addition, oxidant scavengers, such as manganese--(Mn-SOD) and copper/zinc--superoxide dismutase (Cu/Zn-SOD), are thought to contribute to colorectal cancer treatment response. In the present study, the prognostic significance of the Mn- and Cu/Zn-SOD antigen content of normal mucosa and carcinomas of 163 patients with colorectal cancer was evaluated in comparison with major clinicopathological parameters, with respect to the 5-year overall survival. The Mn-SOD content of carcinomas was found to be significantly higher than that of normal mucosa, whereas there was no difference in the Cu/Zn-SOD content between the normal mucosa and carcinomas. No association was demonstrable between the Mn-SOD and Cu/Zn-SOD content of the tissues and the assessed clinicopathological parameters (gender, age, localization, differentiation grade, diameter and Dukes' stage), with the exception of the Cu/Zn-SOD and the differentiation grade of the carcinomas. Univariate analysis showed that a high Mn-SOD content of carcinomas was associated with a poor 5-year overall survival of the patients with colorectal cancer. Multivariate analysis including all clinicopathological parameters revealed that this Mn-SOD parameter was prognostically independent. The Mn- and Cu/Zn-SOD content of normal mucosa and the Cu/Zn-SOD content of carcinomas were not associated with the overall survival of the patients. In conclusion, this study demonstrates that for patients with colorectal cancer the Mn-SOD content of colorectal carcinomas has a significant prognostic value that is independent from major clinicopathological parameters, including Dukes' stage.
活性氧代谢产物与癌症的发生和发展有关。此外，氧化清除剂，如锰超氧化物歧化酶（Mn-SOD）和铜/锌超氧化物歧化酶（Cu/Zn-SOD），被认为有助于结直肠癌的治疗反应。在本研究中，评估了163例结直肠癌患者正常黏膜和癌组织中Mn-SOD和Cu/Zn-SOD抗原含量的预后意义，并与主要临床病理参数进行比较，以观察5年总生存率。结果发现癌组织中Mn-SOD含量明显高于正常黏膜，而正常黏膜和癌组织中Cu/Zn-SOD含量无差异。除癌组织中Cu/Zn-SOD与分化程度外，组织中Mn-SOD和Cu/Zn-SOD含量与评估的临床病理参数（性别、年龄、部位、分化程度、直径和Dukes分期）之间无明显关联。单因素分析显示，癌组织中Mn-SOD含量高与结直肠癌患者5年总生存率低有关。包括所有临床病理参数的多因素分析显示，该Mn-SOD参数在预后方面具有独立性。正常黏膜中Mn-SOD和Cu/Zn-SOD含量以及癌组织中Cu/Zn-SOD含量与患者的总生存率无关。总之，本研究表明，对于结直肠癌患者，结直肠癌组织中Mn-SOD含量具有显著的预后价值，且独立于包括Dukes分期在内的主要临床病理参数。
