用特异性复合物终止获得性和天然免疫耐受。
Termination of aquired and natural immunological tolerance with specific complexes.
作者信息
Habicht G S, Chiller J M, Weigle W O
出版信息
J Exp Med. 1975 Aug 1;142(2):312-20. doi: 10.1084/jem.142.2.312.
It was possible to terminate the induced unresponsive state to bovine serum albumin (BSA) and the natural unresponsive state to autologous thyroglobulin in rabbits (RTg) by immunization with complexes composed of heterologous cross-reacting antibody and the tolerated antigens. The unresponsive state was terminated in rabbits made unresponsive by neonatal injections of BSA and then 3 mo later injected with complexes composed of BSA and guinea pig antihuman serum albumin. This termination was manifested by the presence of anti-BSA plaque-forming cells. Similarly, the natural unresponsive state was terminated in adult rabbits injected with complexes between RTg and guinea pig antibovine thyroglobulin (BTg) in that thyroid lesions and circulating anti-RTg were produced. The results can be best explained by the presence of unresponsive T cells and competent B cells, where the guinea pig gamma globulin (antibody) activates T cells specific for the guinea pig gamma globulin portion of the complexes and thus permits stimulation of B cells competent to the exposed determinants of the tolerated (BSA or RTg) portion of the complexes. The detailed mechanism for the activation of B cells in tolerant animals is discussed.
通过用由异源交叉反应抗体和耐受抗原组成的复合物进行免疫，有可能终止兔对牛血清白蛋白（BSA）的诱导性无反应状态以及对自身甲状腺球蛋白（RTg）的天然无反应状态。在新生期注射BSA后变得无反应，然后在3个月后注射由BSA和豚鼠抗人血清白蛋白组成的复合物的兔中，无反应状态被终止。这种终止表现为抗BSA斑块形成细胞的存在。同样，在注射了RTg与豚鼠抗牛甲状腺球蛋白（BTg）之间的复合物的成年兔中，天然无反应状态被终止，表现为出现甲状腺病变和循环抗RTg。这些结果最好用无反应性T细胞和有反应能力的B细胞的存在来解释，其中豚鼠γ球蛋白（抗体）激活对复合物中豚鼠γ球蛋白部分特异的T细胞，从而允许刺激对复合物中耐受（BSA或RTg）部分暴露的决定簇有反应能力的B细胞。本文讨论了耐受动物中B细胞激活的详细机制。
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