Hallberg M, Johansson P, Kindlundh A M, Nyberg F
Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Uppsala University, Uppsala, Sweden.
Peptides. 2000 Jun;21(6):845-52. doi: 10.1016/s0196-9781(00)00218-7.
The effects of intramuscular (i.m.) injections of nandrolone decanoate (15 mg/kg/day), an anabolic-androgenic steroid, on the levels of substance P (SP) and on its N-terminal fragment SP(1-7) were examined in the male rat brain by radioimmunoassay. The results demonstrated that the SP immunoreactivity in amygdala, hypothalamus, striatum, and periaqueductal gray was significantly enhanced, whereas the concentration of the N-terminal fragment SP(1-7) was enhanced in the nucleus accumbens and in periaqueductal gray. In the striatum the steroid induced a decrease in the content of SP(1-7). The relevance of these peptides in connection with anabolic-androgenic steroid-induced aggression is discussed.
通过放射免疫分析法，研究了在雄性大鼠脑中，肌肉注射癸酸诺龙（15毫克/千克/天，一种合成代谢雄激素类固醇）对P物质（SP）水平及其N端片段SP(1 - 7)的影响。结果表明，杏仁核、下丘脑、纹状体和导水管周围灰质中的SP免疫反应性显著增强，而伏隔核和导水管周围灰质中N端片段SP(1 - 7)的浓度升高。在纹状体中，该类固醇导致SP(1 - 7)含量降低。讨论了这些肽与合成代谢雄激素类固醇诱导的攻击行为之间的相关性。
